机构

• 广州生物医药与健康研... [6]
• 上海药物研究所 [4]
• 植物研究所 [1]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2023 [1]
• 2022 [1]
• 2017 [1]
• 2015 [3]
• 2013 [4]
• 2012 [1]
• 更多

学科主题

• Pharmacolo... [4]
• Biochemist... [3]
• Chemistry [2]
• Chemistry,... [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303 作者:  Xiang, Weiguo;  Zhao, Lijie;  Han, Xin;  Xu, Tianfeng;  Kregel, Steven   |  收藏  |  浏览/下载：23/0  |  提交时间：2023/12/08 An Efficient and Universal Protoplast Isolation Protocol Suitable for Transient Gene Expression Analysis and Single-Cell RNA Sequencing 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 7 作者:  Wang, Juanjuan;  Wang, Yang;  Lu, Tianfeng;  Yang, Xia;  Liu, Jing   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/03/07 protoplast isolation  cell walls  Chirita pumila  protocol  transient gene expression  single-cell RNA sequencing   A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者:  Yu, Lei;  Huang, Minhao;  Xu, Tianfeng;  Tong, Linjiang;  Yan, Xiao-e   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 EGFR(T790M) mutant  Pyrido[2,3-d]pyrimidin-7-ones  Pharmacokinetic property  NSCLC  Irreversible inhibitor   C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 作者:  Ding, Ke;  Ren, Xiaomei;  Zhang, Lianwen;  Yu, Lei;  Luo, Jinfeng   |  收藏  |  浏览/下载：51/0  |  提交时间：2018/12/13 C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 Xu, Tianfeng; Peng, Ting; Ren, Xiaomei; Zhang, Lianwen; Yu, Lei; Luo, Jinfeng; Zhang, Zhang; Tu, Zhengchao; Tong, Linjiang; Huang, Zhaoru; Lu, Xiaoyun; Geng, Meiyu; Xie, Hua; Ding, Jian; Ding, Ke 收藏  |  浏览/下载：71/0  |  提交时间：2016/12/16 C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 作者:  Xu, Tianfeng;  Peng, Ting;  Ren, Xiaomei;  Zhang, Lianwen;  Yu, Lei   |  收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08 Pyrimido[4,5-d]pyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine(790) to Methionine(790) (T790M) Mutants 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 卷号: 52, 期号: 32 作者:  Zhang, Lianwen;  Ding, Ke;  Wang, Shaomeng;  Ren, Xiaomei;  Li, Honglin   |  收藏  |  浏览/下载：41/0  |  提交时间：2018/12/13 Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor Inhibitors with Improved Pharmacokinetic Properties 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 21 作者:  Xu, Tianfeng;  Ding, Ke;  Ren, Xiaomei;  Tu, Zhengchao;  Lu, Xiaoyun   |  收藏  |  浏览/下载：10/0  |  提交时间：2018/12/13 Pyrimido[4,5-d]pyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine(790) to Methionine(790) (T790M) Mutants 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 卷号: 52, 期号: 32 Xu, Tianfeng; Zhang, Lianwen; Xu, Shilin; Yang, Chao-Yie; Luo, Jinfeng; Ding, Fang; Lu, Xiaoyun; Liu, Yingxue; Tu, Zhengchao; Li, Shiliang; Pei, Duanqing; Cai, Qian; Li, Honglin; Ren, Xiaomei; Wang, Shaomeng; Ding, Ke 收藏  |  浏览/下载：56/0  |  提交时间：2016/12/16 Design, Synthesis, and Biological Evaluation of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl Derivatives as New Irreversible Epidermal Growth Factor Receptor Inhibitors with Improved Pharmacokinetic Properties 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 21 Xu, Shilin; Xu, Tianfeng; Zhang, Lianwen; Zhang, Zhang; Luo, Jinfeng; Liu, Yingxue; Lu, Xiaoyun; Tu, Zhengchao; Ren, Xiaomei; Ding, Ke 收藏  |  浏览/下载：16/0  |  提交时间：2016/12/16