中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [248]
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期刊论文 [270]
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Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer
期刊论文
OAI收割
NATURE IMMUNOLOGY, 2025, 卷号: 26, 期号: 5, 页码: 46
作者:
Zhu, Qingchen
;
Zhang, Guiheng
;
Cao, Ming
;
Huang, Huan
;
He, Dan
  |  
收藏
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浏览/下载:0/0
  |  
提交时间:2025/06/23
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 18, 页码: 15469-15481
作者:
Wu, Xinyuan
;
Pan, Jiayi
;
Fan, Rufeng
;
Zhang, Yiwei
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/23
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Wu, Xinyuan
;
Li, Shunyao
;
Liang, Ting
;
Yu, Qing
;
Zhang, Yiwei
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
Activity-based protein profiling data
Covalent DNA-encoded chemical library
Covalent ligand selection
Lysine-targeting covalent inhibitors
Recent advances in targeted degradation in the RAS pathway
期刊论文
OAI收割
FUTURE MEDICINAL CHEMISTRY, 2025, 卷号: 17, 期号: 6, 页码: 693-708
作者:
Ge, Zhiming
;
Fan, Zisheng
;
He, Wei
;
Zhou, Guizhen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/04/24
RAS
cancer
mutation
degrader
PROTAC
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
期刊论文
OAI收割
NATURE CANCER, 2025, 页码: 37
作者:
Wang, Hanling
;
Zhang, Sulin
;
Pan, Qiang
;
Guo, Jiacheng
;
Li, Ni
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
P2DFlow: A Protein Ensemble Generative Model with SE(3) Flow Matching
期刊论文
OAI收割
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2025, 卷号: 21, 期号: 6, 页码: 3288-3296
作者:
Jin, Yaowei
;
Huang, Qi
;
Song, Ziyang
;
Zheng, Mingyue
;
Teng, Dan
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/04/24
Geriatric Nutritional Risk Index is an effective prognostic predictor for metastatic/recurrent or unresectable esophageal cancer receiving immunotherapy
期刊论文
OAI收割
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2025, 卷号: 16, 期号: 1, 页码: 22
作者:
Wang, Bei
;
Wang, Zixuan
;
Xu, Chuanhai
;
Wang, Yueqin
;
Gao, Honglan
  |  
收藏
  |  
浏览/下载:0/0
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提交时间:2025/05/27
Geriatric Nutritional Risk Index (GNRI)
esophageal squamous cell carcinoma (ESCC)
immune checkpoint inhibitors (ICIs)
programmed cell death ligand 1 (PD-L1)
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel
Hs
ClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
作者:
Sun, Mingyang
;
Chen, Beijing
;
Teng, Dan
;
Zhao, Hongshen
;
Liao, Yilie
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/01
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21
作者:
Sui, Qibang
;
Zhou, Yuanyang
;
Li, Manjia
;
Wang, Dan
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/12/25
Synthetic lethal
MSI tumors
WRN inhibitors
Triazolo-pyrimidine derivatives