中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [47]
自动化研究所 [11]
西北高原生物研究所 [9]
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期刊论文 [130]
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Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 15
作者:
Ren, Qun
;
Qu, Ning
;
Sun, Jingjing
;
Zhou, Jingyi
;
Liu, Jin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
kinome profiling
kinase inhibitors
polypharmacology
deep learning
meta-learning
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window
期刊论文
OAI收割
ADVANCED HEALTHCARE MATERIALS, 2023, 页码: 12
作者:
Ji, Yiming
;
Bai, Xue
;
Sun, Hongyan
;
Wang, Luyao
;
Gan, Chunyuan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/22
ferrofluid robots
biocompatibility
targeted therapy
Automatic landslide identification by Dual Graph Convolutional Network and GoogLeNet model-a case study for Xinjiang province, China
期刊论文
OAI收割
FRONTIERS IN EARTH SCIENCE, 2023, 卷号: 11, 页码: 13
作者:
Ma, Shiwei
;
Li, Shouding
;
Bi, Xintao
;
Qiao, Hua
;
Duan, Zhigang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/28
geological disaster
landslide identification
GoogLeNet model
Dual Graph Convolutional Network
model
Role of Nano-SiO2 Dispersion in Tetrahydrofuran Hydrate Induction Time through Image Analyses
期刊论文
OAI收割
ENERGY & FUELS, 2023, 页码: 10
作者:
Sun, Chuanwen
;
Liu, Shimin
;
Li, Shouding
;
Wang, Kai
;
Sun, Yiming
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/01/02
Theoretical Analysis of the Effect of Electrical Heat In Situ Injection on the Kerogen Decomposition for the Development of Shale Oil Deposits
期刊论文
OAI收割
ENERGIES, 2023, 卷号: 16, 期号: 13, 页码: 23
作者:
Montilla, Maryelin Josefina Briceno
;
Li, Shouding
;
Zhang, Zhaobin
;
Li, Xiao
;
Sun, Yiming
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/02
in situ conversion
kerogen decomposition
numerical model
heat transfer
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11
作者:
Yang, Yun
;
Xiong, Yuan
;
Zhu, Guanghao
;
Sun, Mengru
;
Zou, Kun
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
Human carboxylesterase 2 (hCES2A)
Berberine analogues
Structure -activity relationships (SAR)
Inhibition kinetics
Selectivity
Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 6, 页码: 2601-2612
作者:
Wang, Xiaomin
;
Xu, Jun
;
Sun, Yiming
;
Cao, Siyuwei
;
Zeng, Hanlin
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/10/17
HDAC inhibitors
Drug resistance
Histone methylation
Histone acetylation
Epigenetic interplay
Hedgehog pathway
ZIC1
LIFR
Combination therapy
Breast cancer
A shock flash breaking out of a dusty red supergiant
期刊论文
OAI收割
NATURE, 2023
作者:
Li, Gaici
;
Hu, Maokai
;
Li, Wenxiong
;
Yang, Yi
;
Wang, Xiaofeng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/03/29