中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [54]
上海硅酸盐研究所 [24]
地理科学与资源研究... [17]
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期刊论文 [127]
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The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα
期刊论文
OAI收割
CELL METABOLISM, 2025, 卷号: 37, 期号: 11, 页码: 2149-2166
作者:
Xie, Zhifu
;
Cheng, Long
;
Hu, Yue
;
Song, Gaolei
;
Wang, Fan
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收藏
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浏览/下载:0/0
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提交时间:2026/01/28
Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 15, 页码: 15598-15616
作者:
Yang, Yurou
;
Zhai, Jimao
;
Wang, Fan
;
Song, Gaolei
;
Xu, Honghong
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收藏
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浏览/下载:2/0
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提交时间:2025/09/09
Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 8, 页码: 4078-4095
作者:
Miao, Yumeng
;
Lin, Tzuchun
;
Wang, Bianlin
;
Xu, Junyu
;
Li, Chongxian
  |  
收藏
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浏览/下载:2/0
  |  
提交时间:2025/12/04
Xanthohumol derivative
Macrophages
Acute liver failure
Diacylglycerol kinase zeta
Phosphatidic acid
Signal transducer and activator of transcription 3
Interleukin-1/3
Inflammation
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
期刊论文
OAI收割
THERANOSTICS, 2025, 卷号: 15, 期号: 10, 页码: 4325-4344
作者:
Zhang, Zhidan
;
Chen, Meijie
;
Xu, Yitong
;
Wang, Zhihua
;
Liu, Zhenghong
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收藏
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浏览/下载:51/0
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提交时间:2025/06/23
Atherosclerosis
Hyperlipidemia
ATP-Citrate lyase (ACLY)
lipid metabolism
Isoginkgetin
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794
作者:
Liu, Yun
;
Yu, Chengyin
;
Zhang, Yifan
;
Xie, Zhifu
;
Wang, Yating
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收藏
  |  
浏览/下载:27/0
  |  
提交时间:2025/04/24
safety
tolerability
pharmacokinetics
pharmacodynamics
BGT-002
novel ACLY inhibitor
Plant diversity modulates hierarchical responses of carbon cycle processes to warming and grazing in an alpine meadow
期刊论文
OAI收割
JOURNAL OF PLANT ECOLOGY, 2025, 卷号: 18, 期号: 2
作者:
Lu, Wangwang
;
Sun, Jianping
;
Li, Bowen
;
Zhou, Yang
;
Luo, Caiyun
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收藏
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浏览/下载:18/0
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提交时间:2025/11/27
hierarchical responses of carbon cycles
plant diversity
warming
summer and winter grazing
alpine meadow
Qinghai-Tibetan Plateau
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Trade-off between growing season length and herbaceous growth on the Third Pole
期刊论文
OAI收割
JOURNAL OF PLANT ECOLOGY, 2025, 卷号: 18, 期号: 4
作者:
Meng, Fandong
;
Sun, Jianping
;
Lu, Wangwang
;
Zhang, Zhenhua
;
Li, Bowen
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收藏
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浏览/下载:15/0
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提交时间:2025/11/27
leaf economic spectrum
plant functional traits
phenology
common garden
Tibetan Plateau
Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16
作者:
Nie, Hui-Jun
;
Li, Ben-Fu
;
Sun, Jingya
;
Yuan, Yali
;
Zhang, Zhi-Gao
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收藏
  |  
浏览/下载:75/0
  |  
提交时间:2024/11/26
Triple-negative breast cancer
Targeting transcription regulation
Orally bioavailable degrader
PROTAC
Cyclin-dependent Kinase 9
Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489
作者:
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收藏
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浏览/下载:62/0
  |  
提交时间:2025/02/28
metabolic diseases
ATP-citrate lyase (ACLY)
lipogenesis
ACLY inhibitors
dienyldicarboxylic acid
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 12, 页码: 10035-10056
作者:
Wang, Wen-Jing
;
Gao, Lixin
;
Wang, Simei
;
Huang, Wensi
;
Meng, Xin-Yu
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收藏
  |  
浏览/下载:63/0
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提交时间:2024/08/20