中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
合肥物质科学研究院 [22]
近代物理研究所 [6]
地质与地球物理研究所 [1]
自动化研究所 [1]
采集方式
OAI收割 [30]
内容类型
期刊论文 [29]
会议论文 [1]
发表日期
2021 [1]
2019 [1]
2018 [3]
2017 [15]
2016 [3]
2015 [1]
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学科主题
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共30条,第1-10条
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A Pulsed Oxygenation in Terminal Paleoproterozoic Ocean: Evidence From the Transition Between the Chuanlinggou and Tuanshanzi Formations, North China
期刊论文
OAI收割
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 2021, 卷号: 22, 期号: 5, 页码: 23
作者:
Wei, Beilei
;
Tang, Dongjie
;
Shi, Xiaoying
;
Lechte, Maxwell
;
Zhou, Limin
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/10/25
carbon isotopes
early eukaryotes
I/(Ca plus Mg) ratios
mid-Proterozoic
North China Platform
redox conditions
p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma
期刊论文
OAI收割
CANCER LETTERS, 2019, 卷号: 459, 页码: 50-58
作者:
Zhang, Beilei
;
Wang, Xinan
;
Deng, Jiacong
;
Zheng, Haifeng
;
Liu, Wei
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/12/16
miRNA-16
p53
Sanguinarine
Cell cycle
Apoptosis
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:
Wang, Beilei
;
Wu, Jiaxin
;
Wu, Yun
;
Chen, Cheng
;
Zou, Fengming
  |  
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2019/12/25
CDK9
Kinase inhibitor
Structure-activity relationship
Leukemia
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:
Wang, Qiang
;
Liu, Feiyang
;
Qi, Shuang
;
Qi, Ziping
;
Yan, Xiao-E.
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/06/10
PDGFR kinase
Type II inhibitor
Kinase inhibitor
CEL
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Wu, Hong
;
Qi, Ziping
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:
Chen, Yongfei
;
Wu, Jiaxin
;
Wang, Aoli
;
Qi, Ziping
;
Jiang, Taoshan
  |  
收藏
  |  
浏览/下载:875/0
  |  
提交时间:2018/08/17
Egfr
Alk
Dual Kinase Inhibitor
Non-small Cell Lung Cancer
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:
Wang, Beilei
;
Deng, Yuanxin
;
Chen, Yongfei
;
Yu, Kailin
;
Wang, Aoli
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2018/08/16
Btk
Kinase Inhibitor
Irreversible Inhibitor
Structure-activity Relationship
B-cell Lymphoma
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125
作者:
Liang, Qianmao
;
Chen, Yongfei
;
Yu, Kailin
;
Chen, Cheng
;
Zhang, Shouxiang
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2018/07/26
Btk
Irreversible Inhibitor
Kinase Inhibitor
Structure-activity Relationship
B-cell Lymphoma
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:
Wang, Aoli
;
Li, Xixiang
;
Wu, Hong
;
Zou, Fengming
;
Yan, Xiao-E
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2018/07/26