机构

• 合肥物质科学研究院 [22]
• 近代物理研究所 [6]
• 地质与地球物理研究所 [1]
• 自动化研究所 [1]

采集方式

• OAI收割 [30]

内容类型

• 期刊论文 [29]
• 会议论文 [1]

发表日期

• 2021 [1]
• 2019 [1]
• 2018 [3]
• 2017 [15]
• 2016 [3]
• 2015 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共30条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 A Pulsed Oxygenation in Terminal Paleoproterozoic Ocean: Evidence From the Transition Between the Chuanlinggou and Tuanshanzi Formations, North China 期刊论文  OAI收割 GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 2021, 卷号: 22, 期号: 5, 页码: 23 作者:  Wei, Beilei;  Tang, Dongjie;  Shi, Xiaoying;  Lechte, Maxwell;  Zhou, Limin   |  收藏  |  浏览/下载：34/0  |  提交时间：2021/10/25 carbon isotopes  early eukaryotes  I/(Ca plus Mg) ratios  mid-Proterozoic  North China Platform  redox conditions   p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma 期刊论文  OAI收割 CANCER LETTERS, 2019, 卷号: 459, 页码: 50-58 作者:  Zhang, Beilei;  Wang, Xinan;  Deng, Jiacong;  Zheng, Haifeng;  Liu, Wei   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/12/16 miRNA-16  p53  Sanguinarine  Cell cycle  Apoptosis   Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81 作者:  Liu, Xuesong;  Wang, Beilei   |  收藏  |  浏览/下载：51/0  |  提交时间：2019/01/11 ABL kinase  Kinase inhibitor  ABL mutant  CML   Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916 作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming   |  收藏  |  浏览/下载：77/0  |  提交时间：2019/12/25 CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia   Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384 作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.   |  收藏  |  浏览/下载：75/0  |  提交时间：2019/06/10 PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL   Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424 作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping   |  收藏  |  浏览/下载：54/0  |  提交时间：2019/06/17 Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697 作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan   |  收藏  |  浏览/下载：865/0  |  提交时间：2018/08/17 Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer   Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557 作者:  Wang, Beilei   |  收藏  |  浏览/下载：48/0  |  提交时间：2018/08/16 Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma   Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125 作者:  Liang, Qianmao;  Chen, Yongfei;  Yu, Kailin;  Chen, Cheng;  Zhang, Shouxiang   |  收藏  |  浏览/下载：43/0  |  提交时间：2018/07/26 Btk  Irreversible Inhibitor  Kinase Inhibitor  Structure-activity Relationship  B-cell Lymphoma   Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962 作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E   |  收藏  |  浏览/下载：38/0  |  提交时间：2018/07/26