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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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地质与地球物理研究... [38]
上海硅酸盐研究所 [7]
广州地球化学研究所 [4]
上海药物研究所 [4]
数学与系统科学研究院 [2]
海洋研究所 [2]
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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794
作者:
Liu, Yun
;
Yu, Chengyin
;
Zhang, Yifan
;
Xie, Zhifu
;
Wang, Yating
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/04/24
safety
tolerability
pharmacokinetics
pharmacodynamics
BGT-002
novel ACLY inhibitor
Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
作者:
Zhu, Xueran
;
Cui, Shumin
;
Liu, Xinjing
;
Zhang, Mei
;
Xie, Zhifu
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/31
ATP-Citrate Lyase
BGT-002
Acyl glucuronide metabolite
Pseudo-MRM
LC-MS/MS
Pharmacokinetics
The Effect of Impact Load on the Atomistic Scale Fracture Behavior of Nanocrystalline bcc Iron
期刊论文
OAI收割
NANOMATERIALS, 2024, 卷号: 14, 期号: 4, 页码: 11
作者:
Zhao, Zhifu
;
Wang, Zhen
;
Bie, Yehui
;
Liu, Xiaoming
;
Wei, Yueguang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/04/02
molecular dynamics simulation
nanocrystalline iron
impact load
fracture resistance
fracture ductility
HIF-1 alpha inhibition in macrophages preserves acute liver failure by reducing IL-1 beta production
期刊论文
OAI收割
FASEB JOURNAL, 2023, 卷号: 37, 期号: 9, 页码: 12
作者:
Kong, Xiangrong
;
Liu, Wei
;
Zhang, Xinwen
;
Zhou, Chendong
;
Sun, Xinyu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/17
acute liver failure
cell death
HIF-1 alpha inhibitor
interleukin-1 beta
macrophage
Long-term drying trends since the mid-Holocene in the Qaidam Basin
期刊论文
OAI收割
CATENA, 2023, 卷号: 228, 页码: 14
作者:
Zhang, Ting
;
Wang, Gen
;
Wang, Yongli
;
Wei, Zhifu
;
He, Wei
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/12/29
GDGTs
Climate change
Landscape evolution
Qaidam Basin
Asian summer monsoon
Chemical Weathering Intensity as a Reliable Indicator for Southwest Summer Monsoon Reconstruction: Evidence From Clay Minerals of Qionghai Lake Sediments Since the Last Glacial Maximum
期刊论文
OAI收割
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 2023, 卷号: 24, 期号: 7, 页码: 17
作者:
Yu, Xiaoli
;
Wang, Gen
;
Zhang, Ting
;
Ma, Xueyun
;
Zhang, Xiaomei
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/01/02
clay mineral
chemical weathering intensity
southwest summer monsoon
Last Glacial Maximum
Holocene
Influence of the Late Ordovician-Early Silurian Paleoenvironment and Related Geological Processes on the Organic Matter Accumulation and Carbon Isotope Excursion
期刊论文
OAI收割
PALEOCEANOGRAPHY AND PALEOCLIMATOLOGY, 2023, 卷号: 38, 期号: 7, 页码: 22
作者:
Zhang, Pengyuan
;
Wang, Yongli
;
Wei, Zhifu
;
Wang, Gen
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/01/02
Temperature and Climatic Seasonality Affecting C-3 Versus C-4 Plants Since the Last Deglacial on the Northeastern Tibetan Plateau
期刊论文
OAI收割
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 2023, 卷号: 24, 期号: 4, 页码: 23
作者:
Ma, Xueyun
;
Wei, Zhifu
;
Wang, Yongli
;
Wang, Gen
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/01/02
C-4 plants
compound-specific carbon isotope
lacustrine sediments
n-alkanes
paleoclimate
Long-term drying trend during 51.8-37.5 Ma in the Nangqian Basin, central-eastern Qinghai-Tibet Plateau
期刊论文
OAI收割
FRONTIERS IN EARTH SCIENCE, 2022, 卷号: 10, 页码: 17
作者:
Li, Shangkun
;
Ma, Xueyun
;
Jiang, Shaohua
;
Wang, Gen
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/04/03
biomarkers
paleoclimate
paleovegetation
Nangqian Basin
Qinghai-Tibet Plateau
Strontium isotope and element constraints on the paleoenvironment of the latest Ediacaran in the Sichuan Basin, southeastern Tibetan Plateau
期刊论文
OAI收割
FRONTIERS IN EARTH SCIENCE, 2022, 卷号: 10, 页码: 15
作者:
Zhang, Xiaojun
;
Zhou, Gang
;
Zhang, Pengyuan
;
He, Yuan
;
Wei, Zhifu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/03
strontium isotope
elements
paleoenvironment
Ediacaran Dengying Formation
Sichuan Basin