中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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高能物理研究所 [217]
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From Hit to Lead: Discovery of Novel Selective RIPK1 Inhibitor with Pyridoimidazole Scaffold for the Treatment of Autoimmune Diseases through Phenotypic Screening and Structural Optimization
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 69, 期号: 3, 页码: 3252-3288
作者:
Wan, Jihong
;
Xiong, Xiao-Yu
;
Geng, Zixiang
;
Yuan, Benjun
;
Ma, Youzhen
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2026/04/01
Rebalancing the inflammatory trajectory from inflammatory bowel disease to colitis-associated colorectal cancer via artemisinin-based multitarget therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2026, 页码: 14
作者:
He, Shi-jun
;
Tang, Mei-lin
;
Chen, Li
;
Zuo, Jian-ping
;
Xu, Han-chen
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2026/04/01
inflammatory bowel disease
colorectal cancer
artemisinins
anti-inflammatory therapeutics
immune modulation
carcinogenesis
Multiphase State Transitions and Thermal-Tidal Decoupling in the AM CVn-Type Star V803 Cen
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2026, 卷号: 996, 期号: 2
作者:
Sun, Qi-Bin
;
Qian, Sheng-Bang
;
Zhu LY(朱俐颖)
;
Li, Qin-Mei
;
Liao WP(廖文萍)
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2026/01/12
Distinct links between climate warming, mariculture activities, and coastal benthic ecosystem change
期刊论文
OAI收割
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2026, 卷号: 397, 页码: 13
作者:
Xu, Yong
;
Sui, Jixing
;
Ma, Lin
;
Wang, Jinbao
;
Kou, Qi
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2026/06/02
Climate change
Diversity
Benthic assemblage
Mariculture activity
Temperate bay
Multiwavelength Observations of the Apparently Nonrepeating FRB 20250316A
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 995, 期号: 1
作者:
Li, Ye
;
Sun, Hui
;
Qian, Lei
;
Li, Dong-Yue
;
Hua, Yan-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/12/15
Multi-year polarimetric monitoring of four CHIME-discovered repeating fast radio bursts with FAST
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 8, 页码: 289511
作者:
Feng, Yi
;
Zhang, Yong-Kun
;
Xie, Jintao
;
Yang, Yuan-Pei
;
Qu, Yuanhong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/09/11
radio
fast radio bursts
polarization
Gravitational wave astronomy with TianQin
期刊论文
OAI收割
REPORTS ON PROGRESS IN PHYSICS, 2025, 卷号: 88, 期号: 5
作者:
Li, En-Kun
;
Liu, Shuai
;
Torres-Orjuela, Alejandro
;
Chen, Xian
;
Inayoshi, Kohei
  |  
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2025/05/26
gravitational wave
astronomy
TianQin
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Zhai, Lin-hui
;
Jia, Xing-long
;
Chen, Yu-lu
;
Liu, Mu-yin
;
Zhang, Jing-dan
  |  
收藏
  |  
浏览/下载:148/0
  |  
提交时间:2024/12/25
colchicine
MLN4924
multi-omics analysis
phosphoproteomics
ubiquitinomics
kinase inhibitor
19
F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Wang, Ze-yu
;
Ren, Yong-mei
;
Hu, Shu-wei
;
Zhang, Nai-xia
;
Dong, Meng-xiao
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2024/11/05
COVID-19
simnotrelvir
F-19 qNMR
pharmacokinetics
metabolism
mass balance.