中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [37]
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期刊论文 [178]
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Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9
作者:
Li, Linquan
;
Gu, Xi
;
Meng, Jingyi
;
Wen, Yiming
;
Yi, Jing
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/05/27
p53 Y220C
Synthesis
Structural modification
Drug design
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Development of RelB-targeting small-molecule inhibitors of non-canonical NF-kB signaling with antitumor efficacy
期刊论文
OAI收割
MOLECULAR THERAPY, 2025, 卷号: 33, 期号: 4, 页码: 1519-1534
作者:
Li, Cuifeng
;
Wei, Shuqi
;
Sun, Donglin
;
Yang, Zhuo
;
Wang, Qi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
Neural texture synthesis and style transfer of coal-rock images in coal mine heading faces using very deep convolutional networks
期刊论文
OAI收割
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY, 2025, 卷号: 157, 页码: 20
作者:
Xu, Shuzhan
;
Liu, Quansheng
;
Yu, Honggan
;
Huang, Xing
;
Bo, Yin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/27
Coal-rock recognition
Neural style transfer
Image synthesis
Region similarity transform
VGG network
Bilateral segmentation network
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Effect of high-temperature annealing on terahertz optoelectronic properties of nitrogen-doped polycrystalline diamond
期刊论文
OAI收割
DIAMOND AND RELATED MATERIALS, 2024, 卷号: 149
作者:
Liu, Kaichun
;
Xiao, Huan
;
Xu, Wen
;
Cheng, Yanzhe
;
Cheng, Xingjia
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/11/20
Nitrogen-doped polycrystalline diamond
Terahertz time-domain spectroscopy
Optoelectronic properties
Endocranial morphology of three early-diverging ceratopsians and implications for the behavior and the evolution of the endocast in ceratopsians
期刊论文
OAI收割
PALEOBIOLOGY, 2024, 页码: 13
作者:
Hu, Jinfeng
;
Xu, Xing
;
Zhao, Qi
;
He, Yiming
;
Forster, Catherine A.
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/06/11
Endocranial morphology of three early-diverging ceratopsians and implications for the behavior and the evolution of the endocast in ceratopsians
期刊论文
OAI收割
PALEOBIOLOGY, 2024, 页码: 13
作者:
Hu, Jinfeng
;
Xu, Xing
;
Zhao, Qi
;
He, Yiming
;
Forster, Catherine A.
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/03/28
Dynamic polyphenol nanoparticles boost cuproptosis-driven metalloimmunotherapy of breast cancer
期刊论文
OAI收割
NANO TODAY, 2024, 卷号: 58, 页码: 12
作者:
Zhang, Huijuan
;
Chen, Fangmin
;
Cheng, Wenhao
;
Lai, Yi
;
Hou, Bo
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/10/09
Polyphenol
Cuproptosis
Dynamic covalent bond
Cancer metalloimmunotherapy
Tumor immune microenvironment
Electronic band structure of high-symmetry homobilayers of transition metal dichalcogenides
期刊论文
OAI收割
PHYSICAL REVIEW B, 2024, 卷号: 110
作者:
Zhang, Heng
;
Xu, Wen
;
Xiao, Yiming
;
Peeters, Francois M.
;
Milosevic, Milorad V.
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/11/20