中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
期刊论文
OAI收割
JOURNAL OF SPORT AND HEALTH SCIENCE, 2025, 卷号: 14, 页码: 23
作者:
Guo, Mingwei
;
Shen, Fei
;
Guo, Xiaozhen
;
Zhang, Jun
;
Ma, Ying
  |  
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2025/04/01
Daily variance
Circadian
Muscle strength
Metabolic benefits
Resistance exercise
Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 12
作者:
Wu, Feifei
;
Sun, Jiaqi
;
Xu, Mingyang
;
Li, Huiyu
;
Wei, Jiarui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Macrocycle
Kinase
Inhibitors
HPK1
Cancer immunotherapy
Experimental study on blasthole fracturing caused by stress waves from a cylindrical charge
期刊论文
OAI收割
THEORETICAL AND APPLIED FRACTURE MECHANICS, 2025, 卷号: 139, 页码: 14
作者:
Ren, Meng
;
Yue, Zhongwen
;
Zhou J(周俊)
;
Wang, Xu
;
Xue, Kejun
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/18
Drilling and blasting
Cylindrical charge
Blasthole fracture
Stress wave propagation
Strain field evolution
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 161, 页码: 11
作者:
Xie, Hang
;
Li, Wanchen
;
Han, Xiaoyu
;
Li, Minjun
;
Zhao, Qiang
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/25
RIPK3
Inhibitors
Flavonoids
Co-crystal structure
Anti-necroptosis effect
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 11
作者:
Wang, Ruo-lan
;
Sun, Jun
;
Liu, Heng
;
Guo, Shi-meng
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
growth hormone secretagogue receptor
anamorelin
macimorelin
molecular recognition
PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors
期刊论文
OAI收割
CELL DEATH & DISEASE, 2025, 卷号: 16, 期号: 1, 页码: 13
作者:
Zhang, Xu
;
Xu, Jiao
;
Wang, Xuan
;
Xu, Lan
;
Zhang, Xi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Advancing active compound discovery for novel drug targets: insights from AI-driven approaches
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 12
作者:
Wang, Xing-you
;
Chen, Yang
;
Li, Yu-fan
;
Wei, Chao-yang
;
Liu, Meng-ya
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
AI-driven drug discovery
novel drug targets
molecular design
ligand exploration
phenotypic drug discovery
undruggable targets
Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9
作者:
Li, Linquan
;
Gu, Xi
;
Meng, Jingyi
;
Wen, Yiming
;
Yi, Jing
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/05/27
p53 Y220C
Synthesis
Structural modification
Drug design
Structural insights into the activation of the human prostaglandin E
2
receptor EP1 subtype by prostaglandin E
2
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 20, 页码: 12
作者:
Meng, Xue
;
Li, Yang
;
Xu, Jiuyin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/07/25
prostaglandin E2
EP1
receptor activation
PGE2 selectivity