中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Advancing active compound discovery for novel drug targets: insights from AI-driven approaches
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 12
作者:
Wang, Xing-you
;
Chen, Yang
;
Li, Yu-fan
;
Wei, Chao-yang
;
Liu, Meng-ya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
AI-driven drug discovery
novel drug targets
molecular design
ligand exploration
phenotypic drug discovery
undruggable targets
ATR-FTIR Coupled With Machine Learning Provides a Fast Method for Identifying and Distinguishing 55 Varieties of Fruit-Derived Medicinal Materials
期刊论文
OAI收割
PHYTOCHEMICAL ANALYSIS, 2025, 页码: 13
作者:
Zhao, Wen-jie
;
An, Ya-ling
;
Song, Chun-qian
;
Huang, Yu-shi
;
Zhang, Li-jie
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
ATR-FTIR
fruit-derived medicinal materials
machine learning
species discrimination
Bicyclic polyprenylated acylphloroglucinol-related meroterpenoids as potent DRAK2 inhibitors from
Hypericum patulum
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 10
作者:
Huang, Jin-Chang
;
Jia, Xin-Yu
;
Lv, Yi-Fan
;
Xu, Hong-Hong
;
Han, Ming
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2025/04/01
Hypericum patulum
Hypericaceae
Meroterpenoids
Hyperpatins A-H
Death-associated protein kinase-related
apoptosis-inducing kinase 2
Glucose-stimulated insulin secretion
Analysis of ligustrazine covalent cyclodextrin frameworks in bioinformatics and network pharmacology-based acute lung injury treatment
期刊论文
OAI收割
ARABIAN JOURNAL OF CHEMISTRY, 2025, 卷号: 18, 期号: 4, 页码: 12
作者:
Wu, Di
;
Wang, Xiao Le
;
Jia, Yu
;
He, Si Yu
;
Gao, Ya Ting
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Acute lung injury
Bioinformatics
Covalent cyclodextrin frameworks
Ligustrazine
Pulmonary drug delivery
A holistic strategy for the in-depth discrimination and authentication of 16 citrus herbs and associated commercial products based on machine learning techniques and non-targeted metabolomics
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2025, 卷号: 1745, 页码: 12
作者:
Huang, Yu-shi
;
An, Ya-ling
;
Zheng, Yue-yuan
;
Zhao, Wen-jie
;
Song, Chun-qian
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2025/04/01
Citrus herbs
Discrimination
LC-MS
Machine learning
Differential markers
Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Gan, Su-Ya
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/01/14
Thiazolo[3,2-b][1,2,4]triazole
Salicylic acid
Fe3+ion
Fluorescence property
SHP2
Short-term evolution and risks of debris cloud stemming from collisions in geostationary orbit
期刊论文
OAI收割
ACTA ASTRONAUTICA, 2025, 卷号: 228, 页码: 486-493
作者:
Shu P(舒鹏)
;
Zhao, Meng
;
Li, Zhen-Yu
;
Sun, Wei
;
Li YQ(李语强)
  |  
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2025/01/06
Space debris
Object breakup
Density evolution
Collision probability
Geostationary orbit
Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications
期刊论文
OAI收割
JOURNAL OF MATERIALS CHEMISTRY B, 2025, 页码: 11
作者:
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Gan, Su-Ya
;
Fu, Yi-Qiu
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/04/01
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14
作者:
Chen, Yu-jun
;
Zhao, Yu
;
Yao, Ming-yue
;
Wang, Ya-fang
;
Ma, Ming
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2025/04/01
acute myeloid leukemia
FLT3
p300/CBP
quizartinib resistance
combination strategy
The synthesis and antileukemic activity of 5-substituted thiazolyl urea derivatives
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 115, 页码: 6
作者:
Peng, Cheng
;
Sheng, Li
;
Xu, Gao-Ya
;
Qi, Xiao-Lei
;
Zhou, Yu-Bo
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/12/25
Antileukemic
Thiazolyl
Urea
Synthesis
SAR