中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
Insight into the Origin of Multiwavelength Emissions of PKS 1510-089 Through Modeling 12 SEDs from 2008 to 2015
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 988, 期号: 1
作者:
Lei, Maichang
;
Zheng, Yuan
;
Zhang, Jianfu
;
Yuan, Yuhai
;
Wang JC(王建成)
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/07/21
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/07/28
Characterization of the specific proteins to which HH-A, a drug that alleviates ischemic brain injury, binds in rat plasma
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 7, 页码: 15
作者:
Zhao, Jie
;
Zheng, Yuandong
;
Lei, Peng
;
Zhang, Yuying
;
Zhang, Pingping
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/08/20
Stroke
Covalent binding
HH-A
Ischemic brain injury
Proteomics
Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia
期刊论文
OAI收割
CELL REPORTS MEDICINE, 2025, 卷号: 6, 期号: 6, 页码: 28
作者:
Wang, Cong
;
Li, Zhi
;
Zhu, Xiao
;
Sun, Wanbing
;
Ding, Yue
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/08/20
Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2025, 卷号: 15, 期号: 5, 页码: 15
作者:
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/08/20
PROTAC
Vepdegestrant (ARV-471)
Radiolabeling
In vitro-in vivo extrapolation (IVIVE)
Physiologically based pharmacokinetic
(PBPK) model
Comparison of Hydraulic Fracturing and Deflagration Fracturing Under High-Temperature Conditions in Large-Sized Granite
期刊论文
OAI收割
APPLIED SCIENCES-BASEL, 2025, 卷号: 15, 期号: 5, 页码: 17
作者:
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/06/27
hydraulic fracturing
deflagration fracturing
high-temperature
large-sized model experiments
Cavity oscillation drives pattern formation in early mammalian embryos
期刊论文
OAI收割
CELL REPORTS, 2025, 卷号: 44, 期号: 3, 页码: 115342
作者:
Guo, Zheng
;
Yao, Jie
;
Zheng X(郑旭)
;
Cao, Jialing
;
Lv, Xinxin
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/07/21
cavity oscillation
EPI/PrE segregation
pattern formation
early mammalian embryos
blastocyst
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel
Hs
ClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
作者:
Sun, Mingyang
;
Chen, Beijing
;
Teng, Dan
;
Zhao, Hongshen
;
Liao, Yilie
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/04/01
LSTM-based proxy model combined with wellbore-reservoir coupling simulations for predicting multi-dimensional state parameters in depleted gas reservoirs
期刊论文
OAI收割
COMPUTERS & GEOSCIENCES, 2025, 卷号: 196, 页码: 15
作者:
Zhang, Jinyong
;
Hong, Yi
;
Wang, Lizhong
;
Li, Xiaochun
;
Lei, Hongwu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/06/27
CO 2 sequestration
Wellbore-reservoir coupling
Pressure buildup
Depleted gas reservoirs
LSTM
Prediction