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浏览/检索结果: 共281条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9 作者:  Li, Linquan;  Gu, Xi;  Meng, Jingyi;  Wen, Yiming;  Yi, Jing   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/05/27 p53 Y220C  Synthesis  Structural modification  Drug design   Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Understanding the Activity Performance of Comets 38P/Stephan-Oterma, 64P/Swift-Gehrels and C/2017 M4 (ATLAS) through Broadband Photometric Observations 期刊论文  OAI收割 RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2024, 卷号: 24, 期号: 8, 页码: 085013 作者:  Zhang, Xuan;  Liu, Jin-Zhong;  Wang, Le-Tian   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/10/08 comets: general  comets: individual (38P/Stephan-Oterma, 64P/Swift-Gehrels, C/2017 M4 (ATLAS))  techniques: photometric   Effects of Vegetation Restoration Age on Soil C: N: P Stoichiometry in Yellow River Delta Coastal Wetland of China 期刊论文  OAI收割 CHINESE GEOGRAPHICAL SCIENCE, 2024, 页码: 15 作者:  Cao, Qixue;  Wang, Xiaojie;  Chu, Xiaojing;  Zhao, Mingliang;  Wang, Lianjing   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/10/24 coastal wetland  restoration age  soil C: N: P stoichiometry  soil properties  plant species diversity  Yellow River Delta of China   Absorption, distribution, metabolism and excretion of linaprazan glurate in rats 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 242, 页码: 10 作者:  Zhang, Xinyue;  Liu, Donghui;  Lu, Ming;  Yuan, Yali;  Yang, Chen   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/05/07 Linaprazan glurate  [14C]linaprazan glurate  Linaprazan  ADME  Radio-labeling  P-CAB   Isogeometric Convolution Hierarchical Deep-learning Neural Network: Isogeometric analysis with versatile adaptivity 期刊论文  OAI收割 COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 2023, 卷号: 417, 页码: 46 作者:  Zhang, Lei;  Park, Chanwook;  Lu, Ye;  Li, Hengyang;  Mojumder, Satyajit   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/08 Convolution isogeometric analysis (C-IGA)  Convolution hierarchical deep-learning neural network (C-hiDeNN)  Software 2.0  r-h-p-s-a adaptive finite element method (FEM)  High-order smoothness and convergence   In situ Raman spectroscopic measurement of the 13C/12C ratio in CO2: Experimental calibrations on the effects of fluid pressure, temperature and composition 期刊论文  OAI收割 Chemical Geology, 2023, 卷号: 615, 期号: 2023, 页码: 121201 作者:  Wenwen Lu;  Xiaolin Wang;  Qian Wan;  Wenxuan Hu;  I-Ming Chou   |  收藏  |  浏览/下载：26/0  |  提交时间：2023/01/05 Raman spectroscopy  13C  12C ratio  CO2  Experimental calibration  T-P-x influences   A Mushroom P450-Monooxygenase Enables Regioand Stereoselective Biocatalytic Synthesis of Epoxycyclohexenones 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 49 作者:  Yang,Yan-Long;  Zhou,Man;  Yang,Lin;  Gressler,Markus;  Rassbach,Johannes   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/07/10 Biocatalysis  Biosynthesis  Cytochrome P450  Epoxycyclohexenone  Natural Products  OPPOSITE FACIAL SPECIFICITY  NATURAL-PRODUCTS  STREPTOMYCES LL-C10037  BIOSYNTHESIS  EPOXYQUINONE  CYTOCHROME-P450  FERMENTATION  PANEPOXYDONE  EPOXIDATION  INHIBITION   Implications of plant N/P stoichiometry influenced by arbuscular mycorrhizal fungi for stability of plant species and community in response to nutrient limitation 期刊论文  OAI收割 OIKOS, 2022, 页码: 16 作者:  Liu, Hongfei;  Pausch, Johanna;  Wu, Yang;  Xu, Hongwei;  Liu, Guobin   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/02/13 arbuscular mycorrhizal fungi  C4 grass  interspecific plant interaction  legume  plant stoichiometric homeostasis  soil N and P