机构

• 天津工业生物技术研究... [2]
• 长春光学精密机械与物... [1]
• 上海药物研究所 [1]
• 生态环境研究中心 [1]

采集方式

• OAI收割 [5]

内容类型

• 期刊论文 [4]
• 会议论文 [1]

发表日期

• 2021 [1]
• 2015 [1]
• 2014 [1]
• 2012 [1]
• 2011 [1]

学科主题

筛选

浏览/检索结果: 共5条，第1-5条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 In silico health effect prioritization of environmental chemicals through transcriptomics data exploration from a chemo-centric view 期刊论文  OAI收割 SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 卷号: 762, 页码: - 作者:  Liu, Xian;  Zhang, Huazhou;  Xue, Qiao;  Pan, Wenxiao;  Zhang, Aiqian   |  收藏  |  浏览/下载：13/0  |  提交时间：2021/12/22 Computational toxicology  Environmental chemicals  Health effects prioritization  In silico model  Transcriptomics   Towards more accurate prediction of protein folding rates: a review of the existing web-based bioinformatics approaches 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2015, 卷号: 16, 期号: 2, 页码: 314-324 作者:  Chang, Catherine Ching Han;  Tey, Beng Ti;  Song, Jiangning;  Ramanan, Ramakrishnan Nagasundara 收藏  |  浏览/下载：35/0  |  提交时间：2016/06/23 prediction tool  in silico prediction  machine learning algorithm  prediction model  statistical analysis  molecular biology   Bioinformatics approaches for improved recombinant protein production in Escherichia coli: protein solubility prediction 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2014, 卷号: 15, 期号: 6, 页码: 953-962 作者:  Chang, Catherine Ching Han;  Song, Jiangning;  Tey, Beng Ti;  Ramanan, Ramakrishnan Nagasundara 收藏  |  浏览/下载：39/0  |  提交时间：2016/06/23 protein solubility  heterologous expression  in silico prediction  intracellular expression  machine learning algorithm  prediction model   PID control of glucose concentration in subjects with type 1 diabetes based on a simplified model: An in silico trial (EI CONFERENCE) 会议论文  OAI收割 10th World Congress on Intelligent Control and Automation, WCICA 2012, July 6, 2012 - July 8, 2012, Beijing, China 作者:  Yu L. 收藏  |  浏览/下载：29/0  |  提交时间：2013/03/25 An artificial pancreas system (APS) mimics the function of a real pancreas through monitoring a diabetic's blood glucose and administering the right dose of insulin via an automatic control loop. It is hailed as a promising cure of diabetes  though this technology is still years away from commercial use due to a few technological bottlenecks. The simulation model of insulin-glucose metabolism of type 1 diabetes mellitus (T1DM) is an essential part of APS. In order to simplify the parameter identification task so that the model can be implemented electronically with ease  this paper presents a simplified model based on Routh approximation model reduction method. The results show that the approximation error between the simplified model and the original model is so small that can be neglected. Based on the simplified model  a PID controller is designed to maintain normoglycemia (90mg/dl) in subjects with T1DM. The in silico simulation results show that the glucose concentration is controlled well  the risk of hyperglycemia and hypoglycemia is reduced a lot. This suggests that the simplified model describes the insulin-glucose metabolism process accurately  and the PID control algorithm is well-suitable to guide the further development of an APS. 2012 IEEE.   Structure-based in silico model profiles the binding constant of poorly soluble drugs with beta-cyclodextrin 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 卷号: 42, 期号: 1-2, 页码: 55-64 作者:  Li, Haiyan;  Sun, Jin;  Wang, Yongjun;  Sui, Xiaofan;  Sun, Le   |  收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Poorly soluble drugs  beta-Cyclodextrin inclusion complex  Binding constant  In silico model