机构

• 上海药物研究所 [5]

采集方式

• OAI收割 [5]

内容类型

• 期刊论文 [5]

发表日期

• 2017 [2]
• 2014 [1]
• 2013 [1]
• 2006 [1]

学科主题

筛选

浏览/检索结果: 共5条，第1-5条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun   |  收藏  |  浏览/下载：150/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者:  Yu, Lei;  Huang, Minhao;  Xu, Tianfeng;  Tong, Linjiang;  Yan, Xiao-e   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 EGFR(T790M) mutant  Pyrido[2,3-d]pyrimidin-7-ones  Pharmacokinetic property  NSCLC  Irreversible inhibitor   Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 7, 页码: 2366-2378 作者:  Ji, Xun;  Peng, Ting;  Zhang, Xu;  Li, Jian;  Yang, Wei   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 Irreversible EGFR inhibitor  EGFR T790M/L858R  Thieno[2,3-d]pyrimidines   Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998 作者:  Zhang, Xu;  Peng, Ting;  Ji, Xun;  Li, Jian;  Tong, Linjiang   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 EGFR inhibitor  EGFR T790M/L858R  Binding mode  Irreversible EGFR inhibitor   designsynthesisandantitumorevaluationofanewseriesofnsubstitutedthioureaderivatives 期刊论文  OAI收割 actapharmacologicasinica, 2006, 卷号: 27, 期号: 9, 页码: 1259 作者:  Bing Xiong;  Xishan Xiong;  Hong Liu;  Xiaomin Luo;  Hualiang Jiang   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 EPIDERMAL-GROWTH-FACTOR  TYROSINE KINASE INHIBITORS  STRUCTURE-BASED DISCOVERY  FACTOR RECEPTOR EGFR  IRREVERSIBLE INHIBITORS  CHEMICAL INHIBITORS  BINDING-SITE  PROTEIN  DOMAIN  DOCKING  N-substituted-thiourea derivatives  anti-tumor  SPAC1  tyrosine kinase inhibitor  virtual screening