机构

• 上海药物研究所 [25]
• 上海生物化学与细胞生... [1]
• 兰州化学物理研究所 [1]

采集方式

• OAI收割 [27]

内容类型

• 期刊论文 [25]
• 会议论文 [2]

发表日期

• 2025 [1]
• 2024 [4]
• 2023 [2]
• 2022 [6]
• 2021 [4]
• 2019 [4]
• 更多

学科主题

• Biochemist... [1]
• 分析化学与药物化学 [1]

筛选

浏览/检索结果: 共27条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16 作者:  Tang, Cai-ling;  Li, Yuan-qing;  Du, Xi-kun;  Fang, Xiao-xia;  Guang, Yi-man   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 dynamics simulation  CECR2  covalent inhibitor  allosteric effect   Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20 作者:  Luo, Menglan;  Ye, Yunfei;  Tang, Lu;  Kan, Weijuan;  Chen, Lin   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/11/26 Menin  Covalent inhibitor  Antitumor  Degradation   DNA-Encoded Noncanonical Substrate Library for Protease Profiling 期刊论文  OAI收割 CHEMBIOCHEM, 2024, 页码: 12 作者:  Zhang, Huiya;  Xing, Yuyu;  Yang, Yixuan;  Tang, Bixi;  Zong, Zhaoyun   |  收藏  |  浏览/下载：72/0  |  提交时间：2024/12/16 Protease substrate  DNA-encoded library  Combinatorial peptide library  High-throughput screening  Covalent inhibitor  Noncanonical peptide   Identification of benzo[ b ]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 146, 页码: 15 作者:  Cao, Xin-Yu;  Li, Xinge;  Wang, Feng;  Duan, Yichen;  Wu, Xingmei   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/06/27 Serine synthesis pathway  PHGDH  Stattic  Covalent inhibitor  Antitumor   Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16 作者:  Sun, Yaoliang;  Chen, Zhiwen;  Liu, Guobin;  Chen, Xiaoai;  Shi, Zihan   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/03/25 Inhibitor  Cancer  Threonine tyrosine kinase (TTK)  Covalent   Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 10 作者:  Li, Peizhuo;  Tian, Yucheng;  Shang, Qinghong;  Tang, Cailing;  Hou, Zeng   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/10/17 NPAS3  Covalent inhibitor  Protein -protein interaction  5-nitrothiazole warhead   Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：31/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay   A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 31 作者:  Lou, Jianfeng;  Lu, Yuhang;  Cheng, Jing;  Zhou, Feilong   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/12/13 TEAD  YAP  Palmitoylation  Protein-protein interaction  Covalent inhibitor   Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10 作者:  Song, Jia;  Yang, Rui-rui;  Chang, Jie;  Liu, Ya-dan;  Lu, Cheng-hao   |  收藏  |  浏览/下载：65/0  |  提交时间：2022/11/11 cyclic GMP-AMP synthase  covalent inhibitor  inflammatory bowel disease  high-throughput screening   Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327 作者:  Feng, Xuexin;  Yan, Ziqin;  Zhou, Feilong;  Lou, Jianfeng;  Lyu, Xilin   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/03/21 BFL-1  Apoptosis  Covalent inhibitor  Cytochrome c  BCL-2  Protein-Protein interaction