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	Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16 作者: Lin, Zhitong; Liu, Chen; Yan, Ziqin; Cheng, Jing; Wang, Xiancheng \| 收藏 \| 浏览/下载：29/0 \| 提交时间：2024/06/27 MDM2 p53 p21 Imidazolidinone Apoptosis
	HUWE1基因在肺癌中的作用及其机制研究学位论文 OAI收割北京: 中国科学院大学, 2017 作者: 杨卉慧 \| 收藏 \| 浏览/下载：46/0 \| 提交时间：2019/09/24 肺癌 Huwe1 过表达 P53 P21 Lung Cancer Huwe1 Overexpression P53 P21
	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：41/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	Tetrazolium Violet Induced Apoptosis and Cell Cycle Arrest in Human Lung Cancer A549 Cells 期刊论文 OAI收割 biomolecules & therapeutics, 2012, 卷号: 20, 期号: 2, 页码: 177-182 作者: Zhang, Xiao-Hong; Zhang, Nan; Lu, Jian-Mei; Kong, Qing-Zhong; Zhao, Yun-Feng 收藏 \| 浏览/下载：13/0 \| 提交时间：2013/03/15 A549 cell apoptosis Fas Fas ligand p21 p53 Tetrazolium violet
	p73 alpha regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents 期刊论文 OAI收割 TOXICOLOGY, 2010, 卷号: 270, 期号: 1, 页码: 49-56 Liang, Wei; 梁伟; Lu, Chunhua; Li, Jing; Yin, James Q; Zhao, Robert Chunhua 收藏 \| 浏览/下载：19/0 \| 提交时间：2013/12/24 p73 MSC Chemosensitivity p53 p21 Bax
	碳离子辐射对人肝癌细胞SMMC-7721细胞周期和P53、MDM2及P21表达的影响期刊论文 OAI收割辐射研究与辐射工艺学报, 2006, 卷号: 2006, 期号: 05, 页码: 313-316 王燕玲; 张红; 段昕; 刘兵; 周清明; 李小达; 郝冀芳; 刘辉; 赵卫平 \| 收藏 \| 浏览/下载：12/0 \| 提交时间：2010/10/29 碳离子辐射人肝癌细胞细胞周期 P53 Mdm2 P21