机构

• 昆明植物研究所 [1]
• 生态环境研究中心 [1]

采集方式

• OAI收割 [2]

内容类型

• 学位论文 [1]
• 期刊论文 [1]

发表日期

• 2014 [1]
• 2013 [1]

学科主题

筛选

浏览/检索结果: 共2条，第1-2条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 全氟化合物与脂肪酸靶蛋白的相互作用及干扰效应研究 学位论文  OAI收割 博士, 北京: 中国科学院研究生院, 2014 张连营 收藏  |  浏览/下载：246/0  |  提交时间：2015/06/16 全氟化合物  肝脏型脂肪酸结合蛋白  过氧化物酶体增殖剂激活受体  G-蛋白偶联受体40  信号通路  perfluorinated compounds  liver fatty acid binding protein  peroxisome proliferator-activated receptor γ  G protein coupled receptor 40  signaling pathway.   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：40/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.