机构

• 上海药物研究所 [34]
• 上海生物化学与细胞生... [5]
• 昆明植物研究所 [2]
• 物理研究所 [1]
• 化学研究所 [1]

采集方式

• OAI收割 [43]

内容类型

• 期刊论文 [39]
• 学位论文 [3]
• 会议论文 [1]

发表日期

• 2023 [5]
• 2022 [6]
• 2021 [4]
• 2020 [2]
• 2009 [2]
• 2008 [6]
• 更多

学科主题

• Biochemist... [2]
• Chemistry [2]
• Biochemist... [1]
• Biochemist... [1]
• Biotechnol... [1]
• Cell Biolo... [1]
• 更多

筛选

浏览/检索结果: 共43条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/25 Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial 期刊论文  OAI收割 LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 卷号: 38, 页码: 13 作者:  Wang, Fuxiang;  Xiao, Wen;  Tang, Yimin;  Cao, Mengli;  Shu, Dan   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Covid-19  3CL protease inhibitor  SARS-CoV-2 viral load  Alleviation of COVID-19 symptoms   Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18 作者:  Ren, Pengxuan;  Li, Hui;  Nie, Tianqing;  Jian, Xiaoqin;  Yu, Changyue   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2 期刊论文  OAI收割 European journal of medicinal chemistry, 2023, 卷号: 249, 页码: 115129 作者:  Ren, Pengxuan;  Yu, Changyue;  Zhang, Ruxue;  Nie, Tianqing;  Hu, Qiaoyu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/26 Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 87, 页码: 12 作者:  Zhu, Mengwei;  Fu, Tiantian;  You, Mengyuan;  Cao, Junyuan;  Yang, Hanxi   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/10/17 COVID-19  SARS-CoV-2  3CL protease  Nirmatrelvir  Peptidomimetic inhibitors   Optimized Synthesis of a Key Intermediate of Nirmatrelvir 期刊论文  OAI收割 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2022, 页码: 6 作者:  Qin, Hongjian;  Jin, Chen;  Odilov, Abdullajon;  Bonku, Emmanuel Mintah;  Zhu, Fuqiang   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/04/10 alpha-cyanomethylation  neodymium chloride  hydrogenation  one-pot  cyclic glutamine analog  Nirmatrelvir   Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors 期刊论文  OAI收割 MOLECULES, 2022, 卷号: 27, 期号: 10, 页码: 11 作者:  Wu, Jing;  Feng, Bo;  Gao, Li-Xin;  Zhang, Chun;  Li, Jia   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/08/16 COVID-19  M-pro inhibitors  drug design and synthesis  structure-activity relationships (SAR)   In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 231, 页码: 8 作者:     |  收藏  |  浏览/下载：21/0  |  提交时间：2022/06/15 SARS-CoV-2 3C-Like protease  Covalent inhibitor  Virtual screening  Crystal structure   Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 4, 页码: 2794-2808 作者:  Dai, Wenhao;  Jochmans, Dirk;  Xie, Hang;  Yang, Hang;  Li, Jian   |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16 Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 209, 页码: 8 作者:  Zhu, Dafu;  Su, Haixia;  Ke, Changqiang;  Tang, Chunping;  Witt, Matthias   |  收藏  |  浏览/下载：31/0  |  提交时间：2022/06/15 SARS-CoV-2  3CL protease  Native MS  Traditional Chinese medicine  Natural product