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An MnO2-ZIF-67 immobilized acetylcholinesterase method for acetylcholinesterase activity assay and inhibitor screening from Inula macrophylla based on capillary electrophoresis
期刊论文
OAI收割
Talanta, 2023, 期号: 253, 页码: 124025
作者:
Jia Liu
;
Rui Ma
;
Wei Ha
;
Hai-Xia Zhang
;
Shi YP(师彦平)
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/11/30
Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO2 nanozyme for screening inhibitor from Inula macrophylla
期刊论文
OAI收割
Nanoscale, 2023, 期号: 15, 页码: 17464-17472
作者:
Jia Liu
;
Wei Ha
;
Eshbakova Komila Alibekovna
;
Rui Ma
;
Shi YP(师彦平)
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2023/11/13
An MnO2-ZIF-67 immobilized acetylcholinesterase method for acetylcholinesterase activity assay and inhibitor screening from Inula macrophylla based on capillary electrophoresis
期刊论文
OAI收割
Talanta, 2022, 期号: 253, 页码: 124025
作者:
Jia Liu
;
Rui Ma
;
Wei Ha
;
Hai-Xia Zhang
;
Shi YP(师彦平)
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/11/30
Novel inhibitors of AChE and A0 aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235, 页码: 22
作者:
Liu, Yulin
;
Uras, Giuseppe
;
Onuwaje, Itse
;
Li, Wenlong
;
Yao, Hong
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/08/16
Alzheimer's disease
Donepezil
Sulfone group
AChE inhibitor
Inhibiting A 0 aggregation
Neuroprotection
Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease
期刊论文
OAI收割
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022, 页码: 16
作者:
Zeng, Yan
;
Nie, Lifei
;
Liu, Liu
;
Niu, Chao
;
Li, Yi
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/06/15
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22
作者:
Li, Xiaokang
;
Li, Jinwen
;
Huang, Yunyuan
;
Gong, Qi
;
Fu, Yan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
Alzheimer's disease
Depression
Comorbidity
Multi-target-directed ligands
Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
期刊论文
OAI收割
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 页码: 13
作者:
Guo, Runcong
;
Zhou, Lei
;
Chen, Xiaoyan
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/11/04
DESI
Mass spectrometry imaging
Fluoropezil (DC20)
Brain distribution
Optimization strategy
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 4, 页码: 1844-1855
作者:
Zhou, Yu
;
Fu, Yan
;
Yin, Wanchao
;
Li, Jian
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Discovery and Biological Evaluation of New Selective Acetylcholinesterase Inhibitors with Anti-A beta Aggregation Activity through Molecular Docking-Based Virtual Screening
期刊论文
OAI收割
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 2, 页码: 161-166
作者:
Liu, Guangpu
;
Jiao, Yang
;
Lin, Yongqiang
;
Hao, Haifang
;
Dou, Yanli
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
selective acetylcholinesterase inhibitor
amyloid beta aggregation
neuroprotectant
molecular docking
molecular dynamics simulation
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:
Zhou, Yeheng
;
Sun, Wei
;
Peng, Jiale
;
Yan, Hui
;
Zhang, Li
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/03/18
Acetylcholinesterase
Drug design
N-acylhydrazone
Dementia
Copper-chelating
N-Benzylpiperidine