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• 上海药物研究所 [44]
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• 水生生物研究所 [12]
• 合肥物质科学研究院 [8]
• 海洋研究所 [5]
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• 2023 [7]
• 2022 [11]
• 2021 [6]
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学科主题

• Biochemist... [7]
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筛选

浏览/检索结果: 共144条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303 作者:  Xiang, Weiguo;  Zhao, Lijie;  Han, Xin;  Xu, Tianfeng;  Kregel, Steven   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Developmental regulation of the male urogenital papilla in the male marine teleost black rockfish, Sebastes schlegelii (Hilgendorf, 1880) 期刊论文  OAI收割 BIOLOGY OF REPRODUCTION, 2023, 页码: 13 作者:  Wang, Tao;  Wang, Xueying;  Zhao, Ning;  Liu, Qinghua;  Song, Zongcheng   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/07 androgen  external genitalia  viviparous  ara/arb/mafb/shha   Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 7, 页码: 24 作者:  Li, Xiao;  Li, Fei;  Ye, Fei;  Guo, Haotian;  Chen, Wentao   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991 作者:  Wang, Ao;  Luo, Xianggang;  Meng, Xin;  Lu, Zhengyu;  Chen, Kaixian   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex 期刊论文  OAI收割 CHEMISTRY & BIODIVERSITY, 2023, 页码: 10 作者:  Lin, Rongkun;  Yang, Jie;  Liu, Ting;  Wang, Mingyu;  Ke, Chongrong   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 CDK9  cyclin T1  degrader  hydrophobic tag  protein degradation   Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17 作者:  Li, Qian;  Zhang, Tao;  Song, Peiran;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 Simulating androgen receptor selection in designer yeast 期刊论文  OAI收割 SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022, 卷号: 7 作者:  Zhang, Haoran;  Zhang, Lu;  Xu, Yipeng;  Chen, Shaoyong;  Ma, Zhenyi   |  收藏  |  浏览/下载：18/0  |  提交时间：2022/12/23 Androgen receptor mutations  Androgen receptor antagonists  Prostate cancer  Saccharomyces cerevisiae   Dynamic cellular and molecular characteristics of spermatogenesis in the viviparous marine teleost Sebastes schlegelii 期刊论文  OAI收割 BIOLOGY OF REPRODUCTION, 2022, 页码: 15 作者:  Wang, Xueying;  Liu, Qinghua;  Li, Jun;  Zhou, Li;  Wang, Tao   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/02/01 Sebastes schlegelii  internal fertilization  spermatogenesis  spermiogenesis  single-cell RNA-seq   Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors 期刊论文  OAI收割 ONCOGENE, 2022, 卷号: 41, 期号: 42, 页码: 4754-4767 作者:  Tan, Qilong;  Liu, Ziqun;  Gao, Xiaobo;  Wang, Yibo;  Qiu, Xuefeng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/21