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浏览/检索结果: 共878条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy 期刊论文  OAI收割 Chinese Chemical Letters, 2024, 卷号: 35, 期号: 6, 页码: 108967 作者:  Zhou, Yihan;  Gao, Duo;  Wang, Yaying;  Liang, Li;  Zhang, Qingyu   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/03/26 Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906 作者:     |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/09 Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 20 作者:  Miao, Yunqiu;  Li, Lijun;  Wang, Ying;  Wang, Jiangyue;  Zhou, Yihan   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/13 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 卷号: 257, 页码: 16 作者:  Ma, Bing;  Li, Qing;  Mi, Yingqi;  Zhang, Jingjing;  Tan, Wenqiang   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 Benzimidazole-chitosan quaternary ammonium  salt  Nanogels  pH-responsive  Antioxidant activity  Antitumor activity   Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183 作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 17 作者:  Pu, Congying;  Li, Yize;  Fu, Yixian;  Yan, Yiyang;  Tao, Siyao   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/02/27 AIM2 inflammasome  chemotherapy  gut microbiome  ileal epithelial cells  immune checkpoint blockade  lactobacillus  segmented filamentous bacterium   Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/02/19 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably