中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [18]
西北高原生物研究所 [9]
大连化学物理研究所 [6]
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期刊论文 [59]
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2024 [1]
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Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 22
作者:
Wang, Ao
;
Luo, Xianggang
;
Wang, Yawan
;
Meng, Xin
;
Lu, Zhengyu
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/11/11
Synthesis of Hydantoin Androgen Receptor Antagonists and Study on Their Antagonistic Activity
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 18, 页码: 22
作者:
Ma, Longjun
;
Zhou, Yan
;
Yang, Dehua
;
Wang, Ming-Wei
;
Lu, Wei
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/11
androgen receptor
antagonist
enzalutamide
hydantoin analogs
antiproliferative
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/03/21
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
期刊论文
OAI收割
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 378, 期号: 1, 页码: 20-30
作者:
Wang, Yu
;
He, Yang
;
Yang, Feipu
;
Abame, Melkamu Alemu
;
Wu, Chunhui
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113872
作者:
Hou,Tao
;
Xu,Fangfang
;
Peng,Xingrong
;
Zhou,Han
;
Zhang,Xiuli
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/04/02
Opioid receptors
Dynamic mass redistribution
Natural products
Antagonist
Selectivity
IDENTIFICATION
ANTAGONISTS
SUBSTANCES
NALOXEGOL
AGONISTS
SAFETY
MACA
Efficacy of Pyrotinib in HER2-Overexpressing Salivary Duct Carcinoma With Lung Metastasis: A Case Report
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yang, Zi-yan
;
Huang, Jia-huan
;
Chen, Bo
;
Xu, Chun-wei
;
Lei, Lei
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/11/30
salivary duct carcinoma
tyrosine kinase inhibitor
pyrotinib
HER2 positive
targeted
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
OAI收割
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
  |  
收藏
  |  
浏览/下载:260/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Identification of serotonin 2a receptor as a novel hcv entry factor by a chemical biology strategy
期刊论文
iSwitch采集
Protein & cell, 2019, 卷号: 10, 期号: 3, 页码: 178-195
作者:
Cao, Lin
;
Chen, Jizheng
;
Wang, Yaxin
;
Yang, Yuting
;
Qing, Jie
收藏
  |  
浏览/下载:484/0
  |  
提交时间:2019/05/08
Hcv
Serotonin 2a receptor
Entry
Antiviral drug