中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [2083]
化学研究所 [1291]
西北高原生物研... [1279]
大连化学物理研究... [914]
昆明植物研究所 [776]
上海有机化学研究... [764]
更多
采集方式
OAI收割 [11058]
iSwitch采集 [616]
内容类型
期刊论文 [11303]
学位论文 [230]
会议论文 [116]
专利 [14]
SCI/SSCI论文 [3]
专著 [3]
更多
发表日期
2022 [231]
2021 [341]
2020 [316]
2019 [406]
2018 [542]
2017 [587]
更多
学科主题
Chemistr... [341]
金属有机化学 [295]
Pharmaco... [255]
物理化学 [140]
Biochemi... [139]
有机化学 [117]
更多
筛选
浏览/检索结果:
共11674条,第1-10条
帮助
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
题名升序
题名降序
提交时间升序
提交时间降序
作者升序
作者降序
发表日期升序
发表日期降序
Pharmacological characterizationof tachykinin tetrabranched derivatives
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-36
作者:
Chiara Ruzza
;
Anna Rizzi
;
Davide Malfacini
;
Maria Camilla Cerlesi
;
Federica Ferrari
  |  
收藏
  |  
浏览/下载:174/0
  |  
提交时间:2017/07/24
Tachykinins
Substance p
Pwt2-sp
Nk1 Receptor
Calcium Mobilization
Bioluminescence Resonance Energy Transfer
Guinea Pig Ileum
Rat Urinary Bladder
Nociceptive Behaviour Induced By Spinal Substance p
Mice
Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
Synthesis of 1,4-epoxy-2-aryltetrahydro-1-benzazepines
via
rhodium(
iii
)-catalyzed C-H allylation/intramolecular 1,3-dipolar cycloaddition
期刊论文
OAI收割
CHEMICAL COMMUNICATIONS, 2024, 卷号: 60, 期号: 17, 页码: 2401-2404
作者:
Wang, Xuan
;
Li, Jianlong
;
Du, Haifang
;
Liang, Weihong
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/13
Effective correction of dissolved organic carbon interference in nitrate detection using ultraviolet spectroscopy combined with the equivalent concentration offset method
期刊论文
OAI收割
RSC ADVANCES, 2024, 卷号: 14, 期号: 8, 页码: 5370-5379
作者:
Dong, Jing
;
Tang, Junwu
;
Wu, Guojun
;
Xin, Yu
;
Li, Ruizhuo
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/15
DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser
56
to diminish pancreatic β cell function upon overnutrition
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2024, 卷号: 16, 期号: 733, 页码: 16
作者:
Lu, Yuting
;
Xu, Junyu
;
Li, Yufeng
;
Wang, Ruoran
;
Dai, Chengqiu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/13
Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Chen, Xuetao
;
Wu, Tingting
;
Du, Zhiyan
;
Kang, Wenjing
;
Xu, Rujun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/27
BET
BD1
Bromodomain
Brain-permeable
Multiple sclerosis
Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Liu, Min -Min
;
Yang, Yu-Ting
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/02/27
Imidazo[124] triazole derivatives
Fluorescence property
SHP1
Bioactivity
Cellular imaging
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors