中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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In vitro inhibition of six active sesquiterpenoids in zedoary turmeric oil on human liver cytochrome P450 enzymes
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 322, 页码: 10
作者:
Liu, Suyan
;
Zhao, Yong
;
Tang, Xuan
;
Yang, Junling
;
Pan, Chen
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/02/27
Sesquiterpenoids
Inhibition
CYP450s
Drug-drug interactions
Mechanism
Low-Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 17
作者:
Pu, Congying
;
Li, Yize
;
Fu, Yixian
;
Yan, Yiyang
;
Tao, Siyao
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/02/27
AIM2 inflammasome
chemotherapy
gut microbiome
ileal epithelial cells
immune checkpoint blockade
lactobacillus
segmented filamentous bacterium
Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury
期刊论文
OAI收割
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 2, 页码: 757-764
作者:
Wu, Yueci
;
Sun, Lu-Lu
;
Han, Hai-Hao
;
He, Xiao-Peng
;
Cao, Weiguo
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/26
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/02/19
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics
BARN: Behavior-Aware Relation Network for multi-label behavior detection in socially housed macaques
期刊论文
OAI收割
ZOOLOGICAL RESEARCH, 2023, 卷号: 44, 期号: 6, 页码: 1026-1038
作者:
Yang, Sen
;
Chen, Zhi-Yuan
;
Liang, Ke-Wei
;
Qin, Cai-Jie
;
Yang, Yang
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/22
Macaque behavior
Drug safety
assessment
Multi-label behavior detection
Behavioral
similarity
Relation network
Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L
期刊论文
OAI收割
CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28
作者:
Li, Xin
;
Wu, Xiaowei
;
Nie, Shenyou
;
Zhao, Jidong
;
Yao, Yuan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/19
MLL-rearranged leukemia
super elongation complexes
small-molecule inhibitor
protein-protein interaction
cancer therapeutics
Discovery of novel cGAS inhibitors based on natural flavonoids
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 14
作者:
Li, Jiameng
;
Xiong, Muya
;
Liu, Jiayuan
;
Zhang, Fengping
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/08
Cyclic GMP-AMP synthase
Inhibitor
Flavonoids
Crystal structure
Virtual screening
Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
期刊论文
OAI收割
NEUROSCIENCE BULLETIN, 2023, 页码: 15
作者:
Wu, Peng-Peng
;
Cao, Bi-Rong
;
Tian, Fu-Yun
;
Gao, Zhao-Bing
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/08
Levetiracetam
Epilepsy
Antiseizure medications
Synaptic vesicle protein 2A
Brivaracetam
Padsevonil
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active