中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
昆明植物研究所 [5]
上海应用物理研究所 [4]
广州生物医药与健康研... [2]
生态环境研究中心 [2]
深圳先进技术研究院 [1]
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OAI收割 [37]
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期刊论文 [29]
学位论文 [7]
会议论文 [1]
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2024 [1]
2023 [1]
2022 [1]
2021 [4]
2020 [3]
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药物化学 [2]
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Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16
作者:
He, Yulong
;
Li, Shunyi
;
Zhu, Yueyue
;
Wang, Yujie
;
Chen, Yuqi
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2023/10/17
Structure-activity relationship
FABP4 inhibitor
Biphenyl scaffold
Selectivity
Oral bioavailability
Anti-inflammation
2,2 ',4,4 '-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR gamma Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation
期刊论文
OAI收割
CHEMICAL RESEARCH IN TOXICOLOGY, 2022, 卷号: 35, 期号: 6, 页码: 1023-1035
作者:
Ren, Qidong
;
Xie, Xinni
;
Zhao, Chuanfang
;
Wen, Qing
;
Pan, Ruiying
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/08
ACTIVATED-RECEPTOR-GAMMA
BROMINATED FLAME RETARDANTS
ACID-BINDING PROTEIN
GENE-EXPRESSION
LIGAND-BINDING
DIPHENYL ETHERS
INDOOR DUST
EXPOSURE
CD36
ACCUMULATION
Aurora Kinase A as a Diagnostic and Prognostic Marker of Malignant Mesothelioma
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Guo, Zhenying
;
Shen, Li
;
Li, Ningning
;
Wu, Xiaoxiao
;
Wang, Canming
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
malignant mesothelioma
bioinformatics
biomarkers
tissue microarray
Aurora kinase A
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice
期刊论文
OAI收割
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10
作者:
Chen, Meng-Ting
;
Huang, Jun-Shang
;
Gao, Ding-Ding
;
Li, Ying-Xia
;
Wang, He-Yao
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/08/17
combined treatment
FABP4 inhibitor
liver steatosis
obese type 2 diabetes
rosiglitazone
FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105338
作者:
Peng,Xing-Rong
;
Wang,Qian
;
Wang,Hui-Rong
;
Hu,Kun
;
Xiong,Wen-Yong
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/04/02
Ganoderma applanatum
Meroterpenoid dimers
Molecular docking
Anti-lipogenesis
FPR2-based inflammation
INDUCED INSULIN-RESISTANCE
ADIPOCYTE DIFFERENTIATION
OBESITY
INFLAMMATION
DEFICIENCY
MACROPHAGES
ACTIVATION
EXPRESSION
LIGAND
MICE
Hypersampsone P抑制脂肪细胞生成的作用及其机制初探
学位论文
OAI收割
2020
作者:
周慧敏
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2023/11/02
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106
作者:
Su, Haixia
;
Zou, Yi
;
Chen, Guofeng
;
Dou, Huixia
;
Xie, Hang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
期刊论文
OAI收割
ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596
作者:
Dou, Hui-Xia
;
Wang, Ting
;
Su, Hai-Xia
;
Gao, Ding-Ding
;
Xu, Ye-Chun
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
eFABP4
Adipocyte
Differentiation
Lipolysis
Inflammation