机构

• 上海药物研究所 [10]
• 上海生物化学与细胞生... [1]
• 上海营养与健康研究所 [1]

采集方式

• OAI收割 [12]

内容类型

• 期刊论文 [12]

发表日期

• 2022 [1]
• 2021 [1]
• 2020 [3]
• 2018 [1]
• 2017 [1]
• 2016 [1]
• 更多

学科主题

• Genetics &... [1]
• Science & ... [1]

筛选

浏览/检索结果: 共12条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 17 作者:  Jiao, Ting-ying;  Ma, Yuan-di;  Guo, Xiao-zhen;  Ye, Yun-fei;  Xie, Cen   |  收藏  |  浏览/下载：16/0  |  提交时间：2022/06/15 bile acids  nonalcoholic fatty liver disease  nonalcoholic steatohepatitis  drug target  Farnesoid X receptor  G protein-coupled bile acid receptor   Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199 作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan   |  收藏  |  浏览/下载：41/0  |  提交时间：2021/11/04 A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters 期刊论文  OAI收割 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14 作者:  Wang, Ying;  Zhu, Yao;  Niu, Junxing;  Deng, Qiangqiang;  Guo, Shimeng   |  收藏  |  浏览/下载：49/0  |  提交时间：2020/12/21 Bile acid analog  NASH  TGR5  Cd36  AMPK alpha   Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12 作者:  Han, Fanghui;  Ning, Mengmeng;  Cao, Hua;  Ye, Yangliang;  Feng, Ying   |  收藏  |  浏览/下载：18/0  |  提交时间：2020/12/21 Soft drug  TGR5  GLP-1  Gallbladder-filling effects  Rapid metabolism  Carboxylic ester   Structural basis of GPBAR activation and bile acid recognition 期刊论文  OAI收割 NATURE, 2020, 页码: 29 作者:  Yang, Fan;  Mao, Chunyou;  Guo, Lulu;  Lin, Jingyu;  Ming, Qianqian   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24 Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors 期刊论文  OAI收割 SCIENTIFIC REPORTS, 2018, 卷号: 8, 期号: -, 页码: 8084 作者:  Liu, Xuyang;  Wu, Yiran;  Stevens, Raymond C.;  Zhao, Suwen;  Gao, Zhan-Guo   |  收藏  |  浏览/下载：8/0  |  提交时间：2020/12/09 bile acids  dipeptidyl peptidase-4 inhibitor  obesity  saxagliptin  type 2 diabetes   Bile acid signaling and bariatric surgery 期刊论文  OAI收割 Liver research, 2017, 卷号: 1, 期号: 4, 页码: 208-213 作者:  Tian, Jingyan;  Huang, Silvia;  Sun, Siming;  Ding, Lili;  Zhang, Eryun   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339 作者:  Chen, Zhixiang;  Ning, Mengmeng;  Zou, Qingan;  Cao, Hua;  Ye, Yangliang   |  收藏  |  浏览/下载：9/0  |  提交时间：2019/01/08 Takeda G-protein-coupled receptor 5 agonist  bioisostere  microsomal clearance  structure-activity relationship   Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury 期刊论文  OAI收割 Drug metabolism and disposition: the biological fate of chemicals, 2015, 卷号: 43, 期号: 11, 页码: 1751-9 作者:  Li, Xiuli;  Zhong, Kan;  Guo, Zitao;  Zhong, Dafang;  Chen, Xiaoyan   |  收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 11, 页码: 1463-1472 作者:  Wang, Xiao-yin;  Zhang, Shu-yong;  Li, Jing;  Liu, Hua-nan;  Xie, Xin   |  收藏  |  浏览/下载：7/0  |  提交时间：2019/01/08 TGR5  activator  betulinic acid derivatives  GLP-1  lipophilic  structure modifications