中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页
机构
成果
学者
登录
注册
登陆
×
验证码:
换一张
忘记密码?
记住我
×
校外用户登录
CAS IR Grid
机构
上海药物研究所 [59]
上海生物化学与细胞生... [8]
自动化研究所 [5]
广州生物医药与健康研... [3]
过程工程研究所 [3]
合肥物质科学研究院 [3]
更多
采集方式
OAI收割 [89]
iSwitch采集 [2]
内容类型
期刊论文 [87]
学位论文 [4]
发表日期
2023 [6]
2022 [10]
2021 [6]
2020 [6]
2019 [5]
2018 [7]
更多
学科主题
药物化学 [3]
Biochemist... [2]
Biochemist... [2]
Chemistry [2]
Pharmacolo... [2]
Cell Biolo... [1]
更多
筛选
浏览/检索结果:
共91条,第1-10条
帮助
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
提交时间升序
提交时间降序
发表日期升序
发表日期降序
题名升序
题名降序
作者升序
作者降序
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
期刊论文
OAI收割
CELL CHEMICAL BIOLOGY, 2023, 卷号: 30, 期号: 11, 页码: 1421-+
作者:
Xiao, Yufeng
;
Hale, Seth
;
Awasthee, Nikee
;
Meng, Chengcheng
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/16
Smilagenin induces expression and epigenetic remodeling of BDNF in alzheimer's disease
期刊论文
OAI收割
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 11
作者:
Yang, Shuangshuang
;
Fan, Lei
;
Zhang, Rui
;
Song, Chenghuan
;
Shi, Jiyun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Alzheimer's disease
Brain-derived neurotrophic factor
Histone acetylation
Smilagenin
Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2023, 页码: 20
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Lu, Wei
;
Zhu, Shulei
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2023/10/17
EGFR
HER2
NAMPT
Resistance
Selectivity
Molecular docking
Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 6, 页码: 2601-2612
作者:
Wang, Xiaomin
;
Xu, Jun
;
Sun, Yiming
;
Cao, Siyuwei
;
Zeng, Hanlin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
HDAC inhibitors
Drug resistance
Histone methylation
Histone acetylation
Epigenetic interplay
Hedgehog pathway
ZIC1
LIFR
Combination therapy
Breast cancer
Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 10, 页码: 7016-7037
作者:
Li, Daqiang
;
Zhang, Zhuo
;
Li, Yalei
;
Wang, Xinyi
;
Zhong, Hanyue
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
期刊论文
OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 2, 页码: 692-704
作者:
Hu, Zonglong
;
Wei, Fan
;
Su, Yi
;
Wang, Yafang
;
Shen, Yanyan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/27
Proteomic characterization of post-translational modifications in drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 18
作者:
Zhai, Lin-hui
;
Chen, Kai-feng
;
Hao, Bing-bing
;
Tan, Min-jia
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/04/10
proteomics
protein post-translational modification
drug target
off-target
drug mechanism
precision medicine
Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors
期刊论文
OAI收割
BMC Medicine, 2022, 卷号: 20, 期号: 1
作者:
Zhang,Pei
;
Du,Yang
;
Bai,Hua
;
Wang,Zhijie
;
Duan,Jianchun
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/11/21
Tucidinostat
Tumor microenvironment
PD-L1
CCL5
Solid tumor
A dynamic fluorescence probed glycolysis suppression process in HeLa cells treated with trichostatin A
期刊论文
OAI收割
ANALYST, 2022
作者:
Zhang, Fengqiu
;
Shao, Changsheng
;
Wu, Yahui
;
Zhao, Wei
;
Jing, Xumiao
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/22
A near-infrared fluorescent probe was used to evaluate the role of histone deacetylase in pulmonary fibrosis cells and mice
期刊论文
OAI收割
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 卷号: 366, 页码: 8
作者:
Wei, Yinghui
;
Hou, Junjun
;
Lu, Pengpeng
;
Fu, Lili
;
Wang, Xiaoyan
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/07/26
Fluorescent probe
Near-infrared
Histone deacetylases
Idiopathic pulmonary fibrosis
Fluorescence imaging