中国科学院机构知识库网格
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上海药物研究所 [233]
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Nanobodies as negative allosteric modulators for human calcium sensing receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9
作者:
Cui, Qianqian
;
Wang, Lu
;
Wang, Haonan
;
Chen, Xiaochen
;
Han, Li
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/04/09
G-protein-coupled receptor
Extracellular calcium sensing receptor
Nanobody
Cryo-electron microscope
Systemic Ca 2+homoeostasis
Chronic Sacral Nerve Stimulation Inhibits Visceral Hypersensitivity in Diarrhea- Predominant Irritable Bowel Syndrome Rats Model
期刊论文
OAI收割
NEUROMODULATION, 2024, 卷号: 27, 期号: 2, 页码: 295-301
作者:
Guo, Xiaojuan
;
Lei, Changsheng
;
Liang, Hanwei
;
An, Jiaxu
;
Fang, Yanbin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/04/01
Heart rate variability
irritable bowel syndrome
sacral nerve stimulation
transient receptor potential vanilloid 1
visceral hypersensitivity
Paralichthys olivaceus
MLKL-mediated necroptosis is activated by RIPK1/3 and involved in anti-microbial immunity
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15, 页码: 11
作者:
Hao, Kangwei
;
Xu, Hang
;
Jiang, Shuai
;
Sun, Li
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/04/07
Paralichthys olivaceus
necroptosis
RIPK1
RIPK3
MLKL
immune defense
Tumor-Associated Macrophage Targeting of Nanomedicines in Cancer Therapy
期刊论文
OAI收割
PHARMACEUTICS, 2024, 卷号: 16, 期号: 1, 页码: 28
作者:
Kang, Xuejia
;
Huang, Yongzhuo
;
Wang, Huiyuan
;
Jadhav, Sanika
;
Yue, Zongliang
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/02/27
tumor-associated macrophage
suppressive immune environment
tumor proliferation and metastasis
nanomedicine
targeted delivery systems
Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of
Tripterygium
wilfordii
(Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 19
作者:
Cao, Guangchao
;
Ning, Ruonan
;
Zhao, Jie
;
Yao, Jiaying
;
Chang, Linyue
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/11
Tripterygium wilfordii
Dihydro
beta -agarofuran sesquiterpenoid
Osteoclastgenesis
Immunosuppressive
Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators
期刊论文
OAI收割
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 卷号: 50, 期号: 12, 页码: 2856-2868
作者:
Wang, Yun-Qi
;
Guan, Zi-Yue
;
Gao, Zhao-Bing
;
Zheng, Yue-Ming
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/04/09
TRPM7
ion channel
physiological function
disease
small molecule modulators
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
Cui, Shi-hao
;
Suo, Na
;
Yang, Ying
;
Wu, Xuan
;
Guo, Shi-meng
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
oligodendrocyte
oligodendrocyte progenitor cell
differentiation
remyelination
U73122
Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15
作者:
Rao, Danni
;
Yang, Tao
;
Feng, Huixu
;
An, Qi
;
Zhang, Shaofeng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18
作者:
Lu, Lixue
;
Chen, Song
;
Yu, Mingcheng
;
Zhou, Ronghui
;
Guo, Siqi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
ROR gamma t
Triazines
Inverse agonist
Psoriasis
Autoimmune diseases
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran