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浏览/检索结果: 共1419条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Probing the dynamic thermodynamic resolution and biological activity of Cu(II) and Pd(II) complexes with Schiff base ligand derived from proline 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 4, 页码: 7 作者:  Yu, Tao;  Soloshonok, Vadim A.;  Xiao, Zhekai;  Liu, Hong;  Wang, Jiang   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/04/09 Schiff bases  Biological activity  Tailor-made amino acids  Asymmetric synthesis  Chiral tridentate ligands  Square-planar Cu(II)-complexes  Square-planar Pd(II)-complexes   Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins 期刊论文  OAI收割 CELL DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 13 作者:  Cong, Zhaotong;  Zhao, Fenghui;  Li, Yang;  Luo, Gan;  Mai, Yiting   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/03/13 Nanobodies as negative allosteric modulators for human calcium sensing receptor 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9 作者:  Cui, Qianqian;  Wang, Lu;  Wang, Haonan;  Chen, Xiaochen;  Han, Li   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/04/09 G-protein-coupled receptor  Extracellular calcium sensing receptor  Nanobody  Cryo-electron microscope  Systemic Ca 2+homoeostasis   Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma 期刊论文  OAI收割 MOLECULES, 2024, 卷号: 29, 期号: 3, 页码: 14 作者:  Tao, Yimin;  Lu, Wei;  Gao, Jinli;  Yang, Shuangshuang;  Ruan, Chaoyi   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/13 antibody-drug conjugate (ADC)  bioanalysis  anti-drug antibody (ADA)  ligand binding assay (LBA)  ADA-tolerant assay   Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   The emergence of machine learning force fields in drug design 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2024, 页码: 36 作者:  Chen, Mingan;  Jiang, Xinyu;  Zhang, Lehan;  Chen, Xiaoxu;  Wen, Yiming   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/02/19 computational chemistry  drug design  force field  machine learning  molecular modeling   Recognition of methamphetamine and other amines by trace amine receptor TAAR1 期刊论文  OAI收割 NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+ 作者:  Liu, Heng;  Zheng, You;  Wang, Yue;  Wang, Yumeng;  He, Xinheng   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/03/25 Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12 作者:  Zhao, Tian-Tian;  Hu, Hao-Jie;  Gao, Li-Xin;  Zhou, Yu-Bo;  Zhu, Yun-Long   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 Protein tyrosine phosphatases inhibitors  PTP1B inhibitors  Mechanism study  Molecular dynamics   Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 19 作者:  Zhu, Shengnan;  Yuan, Qingning;  Li, Xinzhu;  He, Xinheng;  Shen, Shiyi   |  收藏  |  浏览/下载：96/0  |  提交时间：2024/01/16 different ligands  recognition  ligand selectivity  receptor   The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets