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Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG
期刊论文
OAI收割
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 14
作者:
Liu, Zhipei
;
Wang, Feng
;
Yuan, Hui
;
Tian, Fuyun
;
Yang, Chuanyan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/03/13
hERG
K525N
Gating Polarity
Voltage-Sensing Domain
LQT2
High-redox-capacity solid contact based on ferrocenyl self-assembled monolayer functionalized macroporous gold for an all-solid-state carbonate-selective electrode
期刊论文
OAI收割
MICROCHEMICAL JOURNAL, 2024, 卷号: 197, 页码: 8
作者:
Mu, Shuangqing
;
Yin, Tanji
;
Luan, Feng
;
Qin, Wei
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/01/26
Solid-contact ion-selective electrode
Ferrocenyl self-assembled monolayer
Macroporous gold
Carbonate
Exploiting nonlinear dendritic adaptive computation in training deep Spiking Neural Networks
期刊论文
OAI收割
NEURAL NETWORKS, 2024, 卷号: 170, 页码: 190-201
作者:
Shen, Guobin
;
Zhao, Dongcheng
;
Zeng, Yi
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/02/22
Dendritic Nonlinearity
Dendritic Spatial Gating Module
Dendritic Temporal Adjust Module
Spiking Neural Networks
Blocking tumor-platelet crosstalk to prevent tumor metastasis via reprograming glycolysis using biomimetic membrane-hybridized liposomes
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2024, 卷号: 366, 页码: 328-341
作者:
Zhu, Jie
;
Wang, Rui
;
Yang, Chenxiao
;
Shao, Xinyue
;
Zhang, Yi
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/06
Platelet
Circulating tumor cells (CTCs)
Glycolysis
Metastasis
Hybrid-membrane liposome
Quercetin
Shikonin
Interaction between membrane curvature sensitive factors SpoVM and SpoIVA in Bicelle condition
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 694, 页码: 5
作者:
Chen, Jiali
;
Wang, Yifan
;
Lin, Shuru
;
Yu, Quanxiang
;
Qi, Zhengfei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/27
SpoVM
SpoIVA
Purification
Bicelles
Interaction
SpoVMP9A
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Gu, Yuejiao
;
Ge, Zhiming
;
Tao, Zhaofan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/02/27
Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent
Staphylococcus aureus
Sortase A Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1127-1146
作者:
Yue, Chuan
;
Yuan, Ziqi
;
Xu, Guobin
;
Guan, Xiang-Na
;
Wei, Bingyan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/02/27
The endoplasmic reticulum membrane protein complex subunit Emc6 is essential for rhodopsin localization and photoreceptor cell survival
期刊论文
OAI收割
GENES & DISEASES, 2024, 卷号: 11, 期号: 2, 页码: 1035
作者:
Sun, Kuanxiang
;
Liu, Lu
;
Jiang, Xiaoyan
;
Wang, Heting
;
Wang, Lin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/01
Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2024, 卷号: 479, 页码: 14
作者:
Liu, Bo
;
Han, Gui-Mei
;
Wang, Dong-Xia
;
Liu, Ding -Bin
;
Liu, An -An
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/25
Atherosclerosis
Reactive oxygen species
Biomimetic nanoprobes
In situ
Ratiometric imaging