机构

• 上海药物研究所 [20]
• 合肥物质科学研究院 [7]
• 海洋研究所 [1]
• 上海生物化学与细胞生... [1]

采集方式

• OAI收割 [29]

内容类型

• 期刊论文 [29]

发表日期

• 2024 [1]
• 2023 [5]
• 2022 [5]
• 2021 [4]
• 2020 [8]
• 2019 [3]
• 更多

学科主题

筛选

浏览/检索结果: 共29条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12 作者:  Lin, Ting-ting;  Xiong, Wei;  Chen, Gui-hua;  He, Yang;  Long, Li   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/01/26 osimertinib resistance  targeted drug delivery  liposomes  panobinostat  tumor-associated macrophage  combination therapy   Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2023, 页码: 20 作者:  Ding, Mengyuan;  Shen, Qianqian;  Lu, Wei;  Zhu, Shulei   |  收藏  |  浏览/下载：62/0  |  提交时间：2023/10/17 EGFR  HER2  NAMPT  Resistance  Selectivity  Molecular docking   Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17 作者:  Li, Qian   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割 JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162 作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang   |  收藏  |  浏览/下载：80/0  |  提交时间：2023/04/10 fourth-generation EGFR inhibitor  EGFRC797S mutation  NSCLC  drug resistance  small molecular inhibitor   Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum AlbuminS 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2023, 卷号: 51, 期号: 1, 页码: 8-16 作者:  Wu, Yali;  Chen, Lili;  Chen, Jian;  Xue, Hao;  He, Qingfeng   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S)) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 72, 页码: 11 作者:  Fang, Haotian;  Wu, Yingming;  Xiao, Qitao;  He, Dongbo;  Zhou, Tongrui   |  收藏  |  浏览/下载：72/0  |  提交时间：2022/08/16 Non-small cell lung cancer  EGFR  Triple mutations  C797S  EGFR-TKIs   Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib 期刊论文  OAI收割 BMC CANCER, 2022, 卷号: 22 作者:  Jin, Ying;  Lin, Chen;  Shi, Xun;  He, Qiong;  Yan, Junrong   |  收藏  |  浏览/下载：71/0  |  提交时间：2022/12/23 Clinical and molecular features  Efficacy and outcome  EGFR T790M mutation  Non-small-cell lung cancer  Osimertinib   Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations br 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858 作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang   |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16 Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858 作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/21