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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海生物化学与细胞生... [7]
上海药物研究所 [3]
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OAI收割 [19]
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期刊论文 [18]
学位论文 [1]
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2018 [3]
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应用鞣花酸治疗亨廷顿舞蹈病转基因小鼠的研究
学位论文
OAI收割
: 中国科学院大学, 2020
作者:
孙勋
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/09/07
亨廷顿舞蹈病,鞣花酸,神经炎症,寡聚体,自噬
Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein
期刊论文
OAI收割
FOOD & FUNCTION, 2020, 卷号: 11, 期号: 2, 页码: 1334-1348
作者:
Sun, Xun
;
Zhu, Jie
;
Sun, Xiao-ying
;
Ji, Mei
;
Yu, Xiao-lin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/05/06
Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway
期刊论文
OAI收割
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
作者:
Liu, Shu-ying
;
Yu, Xiao-lin
;
Zhu, Jie
;
Liu, Xiang-meng
;
Zhang, Yue
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2018/10/11
Huntington's Disease
Polyglutamine
Intravenous Immunoglobulin
Huntingtin Protein
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes
期刊论文
OAI收割
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:
Song, Haikun
;
Li, Hexuan
;
Guo, Shimeng
;
Pan, Yuyin
;
Fu, Yuhua
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
GPCR
target validation
polyQ
neurodegeneration
antagonists
PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin
期刊论文
OAI收割
FASEB JOURNAL, 2018, 卷号: 32, 期号: 6, 页码: 2923-2933
作者:
Yang, Hui
;
Yue, Hong-Wei
;
He, Wen-Tian
;
Hong, Jun-Ye
;
Jiang, Lei-Lei
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/04/28
Protein-quality Control
Group-c Protein
Polyglutamine Disease
Alpha-synuclein
Neurodegenerative Diseases
Parkinsons-disease
Nuclear Inclusions
Nucleocytoplasmic Transport
Deubiquitinating Function
Cytoplasmic Inclusions
PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins
期刊论文
OAI收割
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2016
作者:
Li, Chen
;
Nagel, Jeremy
;
Androulakis, Steve
;
Song, Jiangning
;
Buckle, Ashley M.
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2017/03/13
Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2016, 卷号: 17, 期号: 2, 页码: 270-282
作者:
Li, Chen
;
Chang, Catherine Ching Han
;
Nagel, Jeremy
;
Porebski, Benjamin T.
;
Hayashida, Morihiro
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2017/03/13
coiled-coil
prediction
oligomeric state
polyglutamine
Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2014, 卷号: 4, 期号: 1, 页码: 6410-6410
作者:
Yang, H
;
Li, JJ
;
Liu, S
;
Zhao, J
;
Jiang, YJ
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2015/07/22
Autoinhibitory Structure of the WW Domain of HYPB/SETD2 Regulates Its Interaction with the Proline-Rich Region of Huntingtin
期刊论文
OAI收割
STRUCTURE, 2014, 卷号: 22, 期号: 3, 页码: 378-386
作者:
Gao, YG
;
Yang, H
;
Zhao, J
;
Jiang, YJ
;
Hu, HY
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2015/07/22
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntingtons disease
期刊论文
OAI收割
HUMAN MOLECULAR GENETICS, 2013, 卷号: 22, 期号: 18, 页码: 3641-3653
作者:
Wang, Fengli
;
Yang, Yeran
;
Lin, Xiwen
;
Wang, Jiu-Qiang
;
Wu, Yong-Sheng
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2013/10/16
EMBRYONIC STEM-CELLS
ADULT HIPPOCAMPAL NEUROGENESIS
TRANSGENIC MOUSE MODEL
DNA METHYLATION
GENE-EXPRESSION
MUTANT HUNTINGTIN
NERVOUS-SYSTEM
POLYGLUTAMINE PATHOGENESIS
MITOCHONDRIAL DYSFUNCTION
MAMMALIAN DEVELOPMENT