中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2023 [1]
2022 [8]
2021 [1]
2020 [1]
2018 [1]
学科主题
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Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:
Zhang, Jingyu
;
Duan, Haiting
;
Gui, Renzhao
;
Wu, Mingfei
;
Shen, Liteng
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/19
Acute myeloid leukemia
Bromodomain-containing protein 9
Proteolysis-targeting chimera
Orally bioavailable
Docking
Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 15
作者:
Bi, Kaijian
;
Cheng, Junfei
;
He, Shipeng
;
Fang, Yuxin
;
Huang, Min
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
Design, synthesis, and biological evaluation of Wee1 kinase degraders
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 21
作者:
Zhu, Shulei
;
Liu, Jieyu
;
Xiao, Donghuai
;
Wang, Peipei
;
Ma, Jingkun
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/11/11
CRBN
Wee1
PROTAC
Degradation
Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 13
作者:
Cheng, Junfei
;
He, Shipeng
;
Xu, Jun
;
Huang, Min
;
Dong, Guoqiang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/04/10
A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function
期刊论文
OAI收割
CELL REPORTS PHYSICAL SCIENCE, 2022, 卷号: 3, 期号: 10, 页码: 12
作者:
Xu, Yan
;
Fu, Dingqiang
;
Yuan, Yi
;
Peng, Yan
;
Dong, Juan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 239, 页码: 18
作者:
Sun, Yaoliang
;
Zhang, Ying
;
Chen, Xiaoai
;
Yu, Aisong
;
Du, Wenhao
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/08/30
NSD3
PROTAC
Degrader
Methyltransferase
Discovery of a Potent and Selective Degrader for USP7
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395
作者:
Pei, Yuan
;
Fu, Jingfeng
;
Shi, Yunkai
;
Zhang, Mengmeng
;
Luo, Guanghao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/21
Apoptotic Pathway
Mutant p53
p53 Mutant Cancer Cells
PROTAC
USP7 Degrader
NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 6, 页码: 2859-2868
作者:
Wu, Ying
;
Pu, Congying
;
Fu, Yixian
;
Dong, Guoqiang
;
Huang, Min
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/21
NAMPT
Non-enzymatic function
eNAMPT
Cancer
MDSC
PROTAC
Tumor immunity
Immunotherapy
The PROTAC selectively degrading Bcl-x(L) represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while bone
期刊论文
OAI收割
THERANOSTICS, 2022, 卷号: 12, 期号: 17, 页码: 7476-7490
作者:
Zhang, Shaoqing
;
Chen, Yue
;
Xu, Zhongli
;
Yang, Jun
;
Sun, Renhong
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/04/10
Hedgehog
Bcl-xL
PROTAC
drug resistance
bone growth
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN