中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [251]
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Discovery, Optimization, and Evaluation of Novel Pyridin-2(1
H
)-one Analogues as Potent TRK Inhibitors for Cancer Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183
作者:
Xu, Zichao
;
Peng, Xia
;
Zhang, Renjie
;
Ji, Yinchun
;
You, Mengke
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
Opportunities and challenges of fucoidan for tumors therapy
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2024, 卷号: 324, 页码: 13
作者:
Yu, Haoyu
;
Zhang, Quanbin
;
Farooqi, Ammad Ahmad
;
Wang, Jing
;
Yue, Yang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/04/07
Brown algae
Fucoidan
Structure
Anti-tumor
Targeting ST8SIA6-AS1 counteracts KRAS
G12C
inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22
作者:
Wang, Yafang
;
Yao, Mingyue
;
Li, Cheng
;
Yang, Kexin
;
Qin, Xiaolong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
KRAS(G12C)
c-Myc
PLK1
LncRNA
ST8SIA6-AS1
Drug resistance
Mechanisms underlying soil microbial regulation of available phosphorus in a temperate forest exposed to long-term nitrogen addition
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 904, 页码: 12
作者:
Wang, Shiqi
;
Song, Minghua
;
Wang, Chunmei
;
Dou, Xiaomin
;
Wang, Xinqing
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/09
Phosphorus cycling
Nitrogen addition
Functional genes
Phosphorus solubilizing microbes
Phosphatase
K252a inhibition of sperm viability for efficient crossbreeding of hermaphroditic bivalves
期刊论文
OAI收割
AQUACULTURE, 2023, 卷号: 577, 页码: 9
作者:
Liu, Tian
;
Wei, Huilan
;
Zhang, Lijing
;
Liu, Liangjie
;
Li, Yajuan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
K252a
Sperm motility
Crossbreeding
Simultaneous hermaphrodite
Argopecten irradians
Argopecten purpuratus
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups
期刊论文
OAI收割
MARINE DRUGS, 2023, 卷号: 21, 期号: 12, 页码: 21
作者:
Wang, Linqing
;
Guo, Rui
;
Liang, Xiaorui
;
Ji, Yuting
;
Zhang, Jingjing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/01/26
antioxidant activity
carboxymethyl chitosan derivatives
quinoline
Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023, 卷号: 55, 期号: 12, 页码: 1884-1891
作者:
Jin, Shuhan
;
Li, Bo
;
Zhang, Bibo
;
Gao, Xuejie
;
Jia, Xinyan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/02/27
dihydrocelastrol
multiple myeloma
JAK2/STAT3
PSMB5
bortezomib resistance