中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [145]
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Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486
作者:
Chang, Qi
;
Li, Jiayi
;
Deng, Yue
;
Zhou, Ruilin
;
Wang, Bingwei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/25
Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
Lin, Ting-ting
;
Xiong, Wei
;
Chen, Gui-hua
;
He, Yang
;
Long, Li
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/01/26
osimertinib resistance
targeted drug delivery
liposomes
panobinostat
tumor-associated macrophage
combination therapy
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
期刊论文
OAI收割
CELL CHEMICAL BIOLOGY, 2023, 卷号: 30, 期号: 11, 页码: 1421-+
作者:
Xiao, Yufeng
;
Hale, Seth
;
Awasthee, Nikee
;
Meng, Chengcheng
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/16
Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
期刊论文
OAI收割
DIABETES, 2023, 卷号: 72, 期号: 11, 页码: 24
作者:
Pan, Xiaowen
;
Ye, Lingxia
;
Guo, Xiaozhen
;
Wang, Weihua
;
Zhang, Ziyin
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/25
Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 315, 页码: 11
作者:
Ye, Yaqing
;
Xue, Mingzhen
;
Tian, Xiaoting
;
Gao, Hongwei
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
Anemoside B4
Pulsatilla chinensis
metabolite identification
Pharmacokinetics
Rectal suppository
Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells
期刊论文
OAI收割
JOURNAL OF PROTEOME RESEARCH, 2023, 页码: 9
作者:
Sung, Eunji
;
Sim, Hyunchae
;
Cho, Young-Chang
;
Lee, Wonhwa
;
Bae, Jong-Sup
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/11
global proteomics
Kupffer cells
lysine acetylation
lysine lactylation
proteinmodification
Smilagenin induces expression and epigenetic remodeling of BDNF in alzheimer's disease
期刊论文
OAI收割
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 11
作者:
Yang, Shuangshuang
;
Fan, Lei
;
Zhang, Rui
;
Song, Chenghuan
;
Shi, Jiyun
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Alzheimer's disease
Brain-derived neurotrophic factor
Histone acetylation
Smilagenin
HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
期刊论文
OAI收割
CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 17
作者:
Li, Jialun
;
Lu, Lu
;
Liu, Lingling
;
Ren, Xuelian
;
Chen, Jiwei
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/10/17
Integrative Profiling of Lysine Acylome in Sepsis-Induced Liver Injury
期刊论文
OAI收割
JOURNAL OF PROTEOME RESEARCH, 2023, 页码: 11
作者:
Na, Ann-Yae
;
Choi, So Young
;
Paudel, Sanjita
;
Bae, Jong-Sup
;
Tan, Minjia
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
cecum ligation and puncture model
sepsis
lysine acylation
liver dysfunction
protein modification
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 11
作者:
Cai, Haiyan
;
Wang, Yingying
;
Zhang, Jing
;
Wei, Zhenquan
;
Yan, Teng
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17