中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
西北高原生物研究所 [64]
上海药物研究所 [56]
大连化学物理研究所 [33]
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期刊论文 [202]
学位论文 [5]
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2022 [13]
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物理化学 [5]
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Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus)
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 902, 页码: 12
作者:
Yan, Biao
;
Sun, Yumiao
;
Fu, Kaiyu
;
Zhang, Yindan
;
Lei, Lei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
Glyphosate
Metabolomics
Grass carp
Gut-Liver axis
Saikosaponin D improves nonalcoholic fatty liver disease via gut microbiota-bile acid metabolism pathway
期刊论文
OAI收割
Food Science and Human Wellness, 2023
作者:
Li, Lan
;
Yang, Shengye
;
Liang, Xinyu
;
Liu, Yameng
;
Xu, Hualing
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/26
Gut Microbiota
Non-alcoholic Fatty Liver Disease
Ssd
Bile Acids
Farnesoid x Receptor
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
期刊论文
OAI收割
CELL METABOLISM, 2023, 卷号: 35, 期号: 10, 页码: 1752-+
作者:
Kuang, Junliang
;
Wang, Jieyi
;
Li, Yitao
;
Li, Mengci
;
Zhao, Mingliang
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/08
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARa nucleus-cytoplasm shuttling
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18
作者:
Zhong, Jing
;
He, Xiaofang
;
Gao, Xinxin
;
Liu, Qiaohong
;
Zhao, Yu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2023/12/08
Saikosaponins regulate bile acid excretion in mice liver and ileum by activating farnesoid X receptor and bile acid transporter
期刊论文
OAI收割
PHYTOTHERAPY RESEARCH, 2023, 页码: 15
作者:
Wang, YuKun
;
Li, Jing
;
Wu, Li
;
Qin, XueMei
;
Xie, Cen
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
bile acids
enterohepatic circulation
FXR-related genes
saikosaponins
Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities
期刊论文
OAI收割
PHARMACEUTICS, 2022, 卷号: 14, 期号: 12, 页码: 22
作者:
Xie, Ningjie
;
Wang, Hong
;
Qin, Hua
;
Guo, Zitao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
hepatic impairment
ezetimibe
active metabolites
phase II enzymes
transporters
first-pass metabolism
inhibitory bile acids
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16
作者:
Yan, Ying
;
Niu, Zhoumin
;
Sun, Chao
;
Li, Peng
;
Shen, Siyi
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/13
C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice
期刊论文
OAI收割
FRONTIERS IN NUTRITION, 2022, 卷号: 9, 页码: 17
作者:
Zhang, Yubing
;
Li, Lili
;
Qin, Song
;
Yuan, Jingyi
;
Xie, Xiaonan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/01/11
C-phycocyanin
cisplatin
gut microbiota
metabolomics
inflammation
oxidative stress
FAHFAs
chemotherapy
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 21
作者:
Zhang, Chenlu
;
Liu, Yameng
;
Wang, Ying
;
Ge, Xie
;
Jiao, Tingying
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/11/11