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浏览/检索结果: 共76条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Recognition of methamphetamine and other amines by trace amine receptor TAAR1 期刊论文  OAI收割 NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+ 作者:  Liu, Heng;  Zheng, You;  Wang, Yue;  Wang, Yumeng;  He, Xinheng   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/03/25 Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 19 作者:  Zhu, Shengnan;  Yuan, Qingning;  Li, Xinzhu;  He, Xinheng;  Shen, Shiyi   |  收藏  |  浏览/下载：96/0  |  提交时间：2024/01/16 different ligands  recognition  ligand selectivity  receptor   The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Dynamic Interactions Between Brilliant Green and MscL Investigated by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations 期刊论文  OAI收割 CHEMISTRY-A EUROPEAN JOURNAL, 2022, 页码: 12 作者:  Ma, Shaojie;  Zhang, Yan;  Zhang, Xuning;  Xie, Huayong;  Tong, Qiong   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/04/10 Antibiotic  Brilliant Green  mechanosensitive channel of large conductance (MscL)  molecule dynamics simulations  solid-state NMR   Key Considerations in Targeted Protein Degradation Drug Discovery and Development 期刊论文  OAI收割 FRONTIERS IN CHEMISTRY, 2022, 卷号: 10 作者:  Qin, Liena;  Dai, Han;  Wang, Junfeng   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/12/23 targeted protein degradation  PROTAC  molecular glue  chemically induced proximity  drug discovery and development   AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 7 作者:  He, Xin-heng;  You, Chong-zhao;  Jiang, Hua-liang;  Jiang, Yi;  Xu, H. Eric   |  收藏  |  浏览/下载：21/0  |  提交时间：2022/08/16 G protein-coupled receptors  AlphaFold2  protein structure prediction  drug design  structural biology   Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2022, 页码: 2072-2080 作者:  Lu, Haibo;  Zu, Shijia;  Duan, Zhe;  Feng, Yueyao;  Wang, Jie   |  收藏  |  浏览/下载：22/0  |  提交时间：2022/08/16 CECR2 bromodomain  BPTF bromodomain  Inhibitors  Structure-activity relationships  chemical probe   Conserved protein targets for developing pan-coronavirus drugs based on sequence and 3D structure similarity analyses 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 卷号: 145, 页码: 105455 作者:  Ma, Minfei;  Yang, Yanqing;  Wu, Leyun;  Zhou, Liping;  Shi, Yulong   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/03/21 Pharmaceutical informatics  Drug design  Target discovery  Medicinal chemistry  Broad-spectrum drugs   Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 12 作者:  Zhuang, Youwen;  Wang, Lei;  Guo, Jia;  Sun, Dapeng;  Wang, Yue   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15