中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [37]
广州生物医药与健康研... [3]
大连化学物理研究所 [3]
宁波材料技术与工程研... [2]
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期刊论文 [54]
学位论文 [5]
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2023 [1]
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Chemistry [4]
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In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 17
作者:
Du, Shichun
;
Zhai, Linhui
;
Ye, Shu
;
Wang, Le
;
Liu, Muyin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
diabetic kidney disease
type 2 diabetes mellitus
urinary proteome
urinary exosome proteome
biomarkers
Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697
作者:
Han, Fanghui
;
Ning, Mengmeng
;
Wang, Kai
;
Gu, Yipei
;
Qu, Hui
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/21
Bifunctional molecule
Gut-restricted
Ulcerative colitis
TGR5
DPP4
Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
OAI收割
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
  |  
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 1, 页码: 115-120
作者:
Luo, Na
;
Fang, Xiaoyu
;
Su, Mingbo
;
Zhang, Xinwen
;
Li, Dan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/21
Type II diabetes
Dipeptidyl peptidase IV
Inhibitors
Molecular docking
Structure‐ activity relationship
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Ning, Meng-meng
;
Yang, Wen-ji
;
Guan, Wen-bo
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
ulcerative colitis
dextran sulfate sodium
dipeptidyl peptidase 4
sitagliptin
glucagon-like peptide-2
GLP-2(3-33)
apoptosis
proliferation
基于α-葡萄糖苷酶的降糖苦瓜三萜的挖掘
学位论文
OAI收割
2020
作者:
高亚
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2023/11/02
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
OAI收割
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
  |  
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 511, 期号: 2, 页码: 387-393
作者:
Zhang, Hanyan
;
Sun, Dandan
;
Wang, Guanzhen
;
Cui, Shichao
;
Field, Robert A.
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
DPP4
Alogliptin
Liver fibrosis
Hepatic stellate cell
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 5, 页码: 2348-2361
作者:
Li, Shiliang
;
Qin, Chun
;
Cui, Shichao
;
Xu, Hongling
;
Wu, Fangshu
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01