中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [558]
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A Novel Bifunctional Alginate Lyase and Antioxidant Activity of the Enzymatic Hydrolysates
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 卷号: 72, 期号: 8, 页码: 4116-4126
作者:
Gu, Xiaoqian
;
Fu, Liping
;
Wang, Zhiyan
;
Cao, Zhe
;
Zhao, Luying
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/04/07
bifunctional alginatelyase
alginate oligosaccharides
antioxidant activity
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors
Bialorastins A-F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 12
作者:
Yan, Li-Hong
;
Li, Pei-Hai
;
Li, Xiao-Ming
;
Yang, Sui-Qun
;
Liu, Ke-Chun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/04/07
Cold-seep
Penicillium bialowiezense
Meroterpenoids
Proangiogenic activity
Platanosides from Platanus x acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Wu, Xi-Ying
;
Zhao, Ze-Yu
;
Osman, Ezzat E. A.
;
Wang, Xiao-Juan
;
Choo, Yeun-Mun
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/06
Platanus x acerifolia
Platanosides
Molecular ion networking (MoIN)
Antibacterial
Staphylococcus aureus
Enterococcus faecium
Structure -activity relationship (SAR)
Molecular docking
Target validation
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
D3Rings: A Fast and Accurate Method for Ring System Identification and Deep Generation of Drug-Like Cyclic Compounds
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 3, 页码: 724-736
作者:
Ma, Minfei
;
Zhang, Xinben
;
Zhou, Liping
;
Han, Zijian
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/03/13
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways
期刊论文
OAI收割
PHARMACEUTICAL BIOLOGY, 2023, 卷号: 61, 期号: 1, 页码: 1175-1185
作者:
Li, Jiayuan
;
Yu, Jiahe
;
Guo, Jianyou
;
Liu, Jinfeng
;
Wan, Guohui
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2023/10/09
Dyskinesia
neurotransmitters
dopaminergic neurons
nardosinone
molecular docking
oxidative stress
neuroinflammation
>
Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2023, 卷号: 169, 页码: 11
作者:
Bian, Li-hua
;
Wang, Si-qi
;
Li, Wen-jing
;
Li, Jie
;
Yin, Yi
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/18
Depression
Cryptotanshinone
16 S rDNA
Transcriptomics
PI3K-AKT pathway
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics