中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [31]
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Synthesis and biological evaluation of pyrazole-fused oleanolic acid derivatives as novel inhibitors of inflammatory and osteoclast differentiation
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 80, 页码: 117177
作者:
Yu, Yuanyuan
;
Yuan, Wenlong
;
Yuan, Jiaqi
;
Wei, Wenhui
;
He, Qian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/03/27
Osteoarthritis
Oleanolic acid derivatives
Anti-inflammatory
IL-1? inhibition
Antiosteoclastic activity
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15
作者:
Zhu, Cheng-Liang
;
Luo, Xiaomin
;
Tian, Tian
;
Rao, Zijian
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/08/16
AKT
Protein kinase B
PROTAC
Chemical degrader
Rational design
Tailoring Multiple Sites of Metal-Organic Frameworks for Highly Efficient and Reversible Ammonia Adsorption
期刊论文
OAI收割
ACS APPLIED MATERIALS & INTERFACES, 2021, 卷号: 13, 期号: 47, 页码: 56025-56034
作者:
Wang, Zhenzhen
;
Li, Zhiyong
;
Zhang, Xia-Guang
;
Xia, Qingchun
;
Wang, Huiyong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/06/15
ammonia
metal-organic framework
high and reversible capture
multiple-site interactions
hydrogen bonding
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 18, 页码: 13676-13692
作者:
Wang, Jie
;
Wei, Wenhui
;
Zhang, Xiaofei
;
Cao, Shiqi
;
Hu, Bintao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12
作者:
Lin, Tingting
;
Li, Jiacheng
;
Liu, Liping
;
Li, Yuanqing
;
Jiang, Hualiang
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
CDK2 inhibitor
Selectivity
Anti-proliferative potency
Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of alpha,beta-Unsaturated Ketones
期刊论文
OAI收割
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 3, 页码: 908-913
作者:
Liu, Sixiu
;
Qi, Jingjing
;
Lu, Weiwei
;
Wang, Xuan
;
Lu, Xiaojie
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/05/24
Electrochemical oxidation of acid orange 74 using Ru, IrO2, PbO2, and boron doped diamond anodes: Direct and indirect oxidation
期刊论文
OAI收割
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2021, 卷号: 898
作者:
Li, Aiyuan
;
Weng, Jiaqi
;
Yan, Xinmei
;
Li, Hao
;
Shi, Haibo
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/01
WASTE-WATER
BDD ANODE
AQUEOUS-SOLUTIONS
DEGRADATION
DYE
TIRUSNO2
PHENOL
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant
期刊论文
OAI收割
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3234-3237
作者:
Peng, Yingyuan
;
He, Qian
;
Zhang, Xiaofei
;
Yang, Chunhao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 10, 页码: 1187-1193
作者:
Sun, Liangpeng
;
Wang, Peipei
;
Xu, Lili
;
Gao, Lixin
;
Li, Jia
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
PTP1B inhibitor
1,3-Diphenyl-1H-pyrazole
Rhodanine-3-alkanoic acid