中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [648]
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OAI收割 [648]
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期刊论文 [645]
会议论文 [3]
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2024 [4]
2023 [42]
2022 [55]
2021 [60]
2020 [34]
2019 [33]
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Chemistry [13]
Pharmacol... [12]
Biochemist... [9]
Biophysics [3]
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浏览/检索结果:
共648条,第1-10条
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专题:上海药物研究所
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Machine learning prediction for constructing a universal multidimensional information library of
Panax
saponins (ginsenosides)
期刊论文
OAI收割
FOOD CHEMISTRY, 2024, 卷号: 439, 页码: 10
作者:
Wang, Hongda
;
Zhang, Lin
;
Li, Xiaohang
;
Sun, Mengxiao
;
Jiang, Meiting
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/02/19
Retention time
Collision cross section
Machine learning
Multidimensional information library
Hierarchical design
Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Chen, Xuetao
;
Wu, Tingting
;
Du, Zhiyan
;
Kang, Wenjing
;
Xu, Rujun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/27
BET
BD1
Bromodomain
Brain-permeable
Multiple sclerosis
Direct Construction of
C
-Alkyl Glycosides from Non-Activated Olefins via Nickel-Catalyzed C(sp
3
)―C(sp
3
) Coupling Reaction
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 8
作者:
Yu, Changyue
;
Xu, Yinghuan
;
Zeng, Mingjie
;
Wang, Jingjing
;
Dai, Wenhao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/27
C-alkyl glycosides
C(sp3)C(sp3) coupling
non-activated olefins
nickel catalysis
A novel capsid-XL32-derived adeno-associated virus serotype prompts retinal tropism and ameliorates choroidal neovascularization
期刊论文
OAI收割
BIOMATERIALS, 2024, 卷号: 304, 页码: 13
作者:
Luo, Lin-Lin
;
Xu, Jie
;
Wang, Bing-Qiao
;
Chen, Chen
;
Chen, Xi
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/01/26
AAV
Capsid engineering
Phosphosites mutation
Retinal tropism
Neovascularization
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
期刊论文
OAI收割
NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+
作者:
Liu, Heng
;
Zheng, You
;
Wang, Yue
;
Wang, Yumeng
;
He, Xinheng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/02/19
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2023, 卷号: 364, 页码: 23-36
作者:
Xia, Jiaxuan
;
Chen, Chen
;
Dong, Meichen
;
Zhu, Ying
;
Wang, Anni
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/01/16
Ginsenoside Rg3
Liposomes
Polyethylene glycol
Long circulation
Accelerated blood clearance (ABC)
IgM antibody
Complement activation
Repurposing of Rutan showed effective treatment for COVID-19 disease
期刊论文
OAI收割
FRONTIERS IN MEDICINE, 2023, 卷号: 10, 页码: 13
作者:
Salikhov, Shavkat I.
;
Abdurakhmonov, Ibrokhim Y.
;
Oshchepkova, Yuliya I.
;
Ziyavitdinov, Jamolitdin F.
;
Berdiev, Nodir Sh.
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/01/26
COVID-19
SARS-CoV-2
3CLpro
RdRp
Rhus coriaria
Rutan
clinical trial
Discovery of novel isopropanolamine inhibitors against MoTPS1 as potential fungicides with unique mechanisms
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 260, 页码: 14
作者:
Jiang, Zhiyang
;
Shi, Dongmei
;
Chen, Yitong
;
Li, Huilin
;
Wang, Jin 'e
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/08
Rice blast
Trehalose-6-phosphate synthase
Isopropanolamine compounds
Inhibitor
Fungicidal mechanism