中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [126]
采集方式
OAI收割 [126]
内容类型
期刊论文 [123]
会议论文 [3]
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2024 [1]
2023 [4]
2022 [4]
2021 [15]
2020 [12]
2019 [10]
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Biochemist... [1]
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浏览/检索结果:
共126条,第1-10条
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专题:上海药物研究所
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Probing the dynamic thermodynamic resolution and biological activity of Cu(II) and Pd(II) complexes with Schiff base ligand derived from proline
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 4, 页码: 7
作者:
Yu, Tao
;
Soloshonok, Vadim A.
;
Xiao, Zhekai
;
Liu, Hong
;
Wang, Jiang
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/04/09
Schiff bases
Biological activity
Tailor-made amino acids
Asymmetric synthesis
Chiral tridentate ligands
Square-planar Cu(II)-complexes
Square-planar Pd(II)-complexes
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12
作者:
Tang, Shuai
;
Duan, Yichen
;
Yuan, Tao
;
Hu, Yutinh
;
Yuan, Liang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/11
KRAS
Pancreatic ductal adenocarcinoma
MAPK pathway
Tetrandrine
TRAIL
Death receptors
Discovery of zolinium TSG1180 as a novel agonist of transgelin-2 for treating asthma
期刊论文
OAI收割
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, 卷号: 167, 页码: 115556
作者:
Yuan, Hong-Kai
;
Li, Bo
;
Wu, Leyun
;
Wang, Xue-Ling
;
Lv, Zhi-Ying
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/26
Active learning
Consensus labelling
Eye irritation
Serious eye damage
Structural alerts
Constructing N-Acyl/N-Sulfonyl Aza-Sulfur Derivatives from Amides/Sulfonamides and Thiophthalimides via Oxidant Regulation
期刊论文
OAI收割
ORGANIC LETTERS, 2023, 卷号: 25, 期号: 32, 页码: 6018-6023
作者:
Li, Yazhou
;
Wang, Yongkun
;
Fang, Feifei
;
Zhang, Yu
;
Li, Chunpu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/17
Macrocyclization of Maleimide-Decorated Peptides via Late-Stage Rh(III)-Catalyzed Trp(C7) Alkenylation
期刊论文
OAI收割
ORGANIC LETTERS, 2023, 卷号: 25, 期号: 14, 页码: 2456-2460
作者:
Zhang, Yu
;
Hu, Shulei
;
Li, Yazhou
;
Wang, Yongkun
;
Yu, Tao
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/10/17
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
期刊论文
OAI收割
ANTIVIRAL RESEARCH, 2022, 卷号: 208, 页码: 10
作者:
Shang, Weijuan
;
Dai, Wenhao
;
Yao, Cheng
;
Xu, Ling
;
Tao, Xiangming
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
SARS-CoV-2
SARS-CoV-2 variants
FB2001
Main protease
PBPK
Anti-SARS-CoV-2 in vivo
A substrate-controlled Ru(ii)-catalyzed C-H activation/[5+2] annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds
期刊论文
OAI收割
ORGANIC CHEMISTRY FRONTIERS, 2022, 页码: 6
作者:
Zheng, Miao
;
Zhou, Jianhui
;
Fang, Feifei
;
Xu, Zichao
;
Zheng, Fuqiang
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
Design, synthesis and in vitro biological evaluation of marine phidianidine derivatives as potential anti-inflammatory agents
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71, 页码: 116936
作者:
Xu, Quan
;
Zhao, Ning
;
Liu, Jin
;
Song, Jin-Qian
;
Huang, Li-Hua
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/21
Indole alkaloids
Marine natural products
Phidianidines
Anti-inflammatory activities
Molecular docking
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR(T790M/C797S) Mutants
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 7
作者:
Li, Shan
;
Zhang, Tao
;
Zhu, Su-Jie
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/15
Epidermal Growth Factor Receptor (EGFR)
Resistant Mutation
C797S
Antitumor
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification