中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [14]
采集方式
OAI收割 [14]
内容类型
期刊论文 [14]
发表日期
2022 [3]
2021 [1]
2020 [3]
2019 [1]
2018 [3]
2017 [1]
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专题:上海药物研究所
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Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens
期刊论文
OAI收割
FITOTERAPIA, 2022, 卷号: 159, 页码: 10
作者:
Shao, Zhengguang
;
Li, Lizhi
;
Zheng, Yongzhe
;
Gong, Qi
;
Ke, Chang-Qiang
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/08/16
Artemisia atrovirens
Sesquiterpenoid dimer
Guaianolide
TDDFT ECD calculation
Artatrovirenolides A-H
Novel inhibitors of AChE and A0 aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235, 页码: 22
作者:
Liu, Yulin
;
Uras, Giuseppe
;
Onuwaje, Itse
;
Li, Wenlong
;
Yao, Hong
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/08/16
Alzheimer's disease
Donepezil
Sulfone group
AChE inhibitor
Inhibiting A 0 aggregation
Neuroprotection
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22
作者:
Li, Xiaokang
;
Li, Jinwen
;
Huang, Yunyuan
;
Gong, Qi
;
Fu, Yan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
Alzheimer's disease
Depression
Comorbidity
Multi-target-directed ligands
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 4, 页码: 1844-1855
作者:
Zhou, Yu
;
Fu, Yan
;
Yin, Wanchao
;
Li, Jian
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
期刊论文
OAI收割
NATURE BIOMEDICAL ENGINEERING, 2020, 页码: 16
作者:
Wang, Cong
;
Sun, Wanbing
;
Zhang, Jun
;
Zhang, Jianping
;
Guo, Qinghua
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/21
Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 3, 页码: 434-446
作者:
Feng, Hongxuan
;
Hu, Linghao
;
Zhu, Hongwen
;
Tao, Lingxue
;
Wu, Lei
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Blood-brain barrier
Brain ischemia
Cell cycle
Inflammation
Neuroprotection
Neuroprotective Dihydro-beta-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii
期刊论文
OAI收割
JOURNAL OF NATURAL PRODUCTS, 2019, 卷号: 82, 期号: 11, 页码: 3096-3103
作者:
Fu, Yifan
;
Wang, Wei
;
Gong, Qi
;
Zhang, Haiyan
;
Zhao, Weimin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease