中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [40]
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OAI收割 [40]
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期刊论文 [39]
会议论文 [1]
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2022 [1]
2020 [3]
2019 [4]
2018 [9]
2017 [4]
2016 [5]
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专题:上海药物研究所
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A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 20
作者:
Chen, Yaqiong
;
Wang, Jiang
;
Wang, Yibing
;
Wang, Pengfei
;
Zhou, Zan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15
The triterpenoid sapogenin (2 alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling
期刊论文
OAI收割
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 9, 页码: 10
作者:
Xie, Zhifu
;
Jiang, Haowen
;
Liu, Wei
;
Zhang, Xinwen
;
Chen, Dakai
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/21
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
  |  
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188, 页码: 17
作者:
Wang, Junwei
;
Lv, Xue
;
Xu, Jiawen
;
Liu, Xinpeng
;
Du, Te
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Type 2 diabetes mellitus
Pancreatic beta-cells protective agents
Vincamine derivatives
Structural modifications
Structure-activity relationships
TGF-beta 1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
期刊论文
OAI收割
EBIOMEDICINE, 2019, 卷号: 42, 页码: 458-469
作者:
Wang, Kuifeng
;
Fang, Shanhua
;
Liu, Qian
;
Gao, Jing
;
Wang, Xiaoning
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Liver fibrosis
TGF-beta 1
MAT2A
p65
SAM
Synthetic derivatives of the natural product 13-amino 2-desoxy-4-epi-pulchellin inhibit STAT3 signaling and induce G2/M arrest and death of colon cancer cells
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 782-785
作者:
Niu, Junxing
;
Huang, Hui
;
Wang, Fei
;
Zhang, Xianjing
;
Liu, Yi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Sesquiterpene-lactone
JAK2/STAT3
Michael addition reaction
Antitumor
Colorectal carcinoma
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
OAI收割
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
  |  
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
A Thermally Robust La3Si6N11:Ce-in-Glass Film for High-Brightness Blue-Laser-Driven Solid State Lighting
期刊论文
OAI收割
LASER & PHOTONICS REVIEWS, 2019, 卷号: 13, 期号: 2, 页码: 10
作者:
You, Shihai
;
Li, Shuxing
;
Zheng, Peng
;
Zhou, Tianliang
;
Wang, Le
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
color converter
La3Si6N11:Ce
laser lighting and displays
luminescence saturation
phosphor-in-glass film
A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity
期刊论文
OAI收割
ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 5, 页码: 5891-5899
作者:
Wei, Shunfeng
;
Chen, Wantao
;
Hu, Lihong
;
Pan, Jinsong
;
Wang, Xu
  |  
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
multidrug resistance
ATP-binding cassette subfamily B member 1
toxicity
pharmacokinetics
A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2
期刊论文
OAI收割
Investigational new drugs, 2018
作者:
Huang, Hui
;
Niu, Junxing
;
Wang, Fei
;
Hu, Lihong
;
Yu, Qiang
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08