机构

• 上海药物研究所 [29]

采集方式

• OAI收割 [29]

内容类型

• 期刊论文 [29]

发表日期

• 2023 [3]
• 2022 [5]
• 2021 [5]
• 2020 [3]
• 2019 [1]
• 2018 [3]
• 更多

学科主题

筛选

浏览/检索结果: 共29条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15 作者:  Gu, Dongyan;  Zhang, Mengmeng;  Cai, Lvtao;  Wang, Chang;  Zhou, Yu -Bo   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/10/17 PI3K alpha inhibitors  Virtual screening  Structure optimization   Discovery of Highly Potent and Selective Thyroid Hormone Receptor βAgonists for the Treatment of Nonalcoholic Steatohepatitis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3284-3300 作者:  Hu, Liuyu;  Gu, Yipei;  Liang, Ju;  Ning, Mengmeng;  Yang, Junli   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors 期刊论文  OAI收割 PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27 作者:  Zang, Yi;  Su, Mingbo;  Wang, Qingxing;  Cheng, Xi;  Zhang, Wenru   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 high-throughput screening  SARS  CoV-2  main  papain-like  proteases   Discovery of a Potent and Selective Degrader for USP7 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395 作者:  Pei, Yuan;  Fu, Jingfeng;  Shi, Yunkai;  Zhang, Mengmeng;  Luo, Guanghao   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/21 Apoptotic Pathway  Mutant p53  p53 Mutant Cancer Cells  PROTAC  USP7 Degrader   Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18 作者:  Cao, Yu;  Tu, Yutong;  Fu, Liping;  Yu, Qian;  Gao, Lixin   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Metabolism  Design  Proteasome inhibitors  Non-covalent  Multiple myeloma   Construction of Aza-spiro[4,5]indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)-H Activation of Indole 期刊论文  OAI收割 ACTA CHIMICA SINICA, 2022, 卷号: 80, 期号: 3, 页码: 277-281 作者:  Wang Mengmeng;  Zhang Jun;  Wang Huiying;  Ma Biao;  Dai Hui-Xiong   |  收藏  |  浏览/下载：28/0  |  提交时间：2022/06/15 indole spirocycle  C-H activation  Rh-catalyst   Chemical Constituents of Sinularia nanolobata from the South China Sea 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 3, 页码: 891-895 作者:  Zeng Zirong;  Zhang Mengmeng;  Wang Hong;  Li Jia;  Guo Yuewei   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/08/16 south china sea: Sinularia nanolobata  prenylelemane-type diterpene  protein tyrosine phosphatase-1B (PTPIB) inhibitory activity   Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation 期刊论文  OAI收割 THERANOSTICS, 2022, 卷号: 12, 期号: 11, 页码: 5220-5236 作者:  Guo, Ren;  Jia, Xiaohui;  Ding, Zhenbin;  Wang, Gang;  Jiang, Mengmeng   |  收藏  |  浏览/下载：40/0  |  提交时间：2022/08/30 Mixed lineage kinase domain-like protein  MLKL  liver fibrosis  liver parenchymal cells  hepatocyte  hepatic stellate cells  necroptosis   Development of peptide epoxyketones as selective immunoproteasome inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 221, 页码: 113556 作者:  Li, Xuemei;  Hong, Duidui;  Zhang, Mengmeng;  Xu, Lei;  Zhou, Yubo   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/21 Epoxyketones  Immunoproteasome inhibitor  Selectivity  Multiple myeloma   Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries 期刊论文  OAI收割 CHEMICAL COMMUNICATIONS, 2021, 页码: 4 作者:  Zhang, Jun;  Wang, Mengmeng;  Wang, Huiying;  Xu, Hui;  Chen, Junjie   |  收藏  |  浏览/下载：37/0  |  提交时间：2021/11/04