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14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-kappa B/Sirtuin 2-NLRP3-mediated adipose tissue remodeling 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 12
作者:  Chen, Jia-li;  Feng, Zhe-ling;  Zhou, Fei;  Lou, Ruo-han;  Peng, Cheng
  |  收藏  |  浏览/下载：21/0  |  提交时间：2022/09/30
Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain 期刊论文  OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2022, 页码: 2072-2080
作者:  Lu, Haibo;  Zu, Shijia;  Duan, Zhe;  Feng, Yueyao;  Wang, Jie
  |  收藏  |  浏览/下载：24/0  |  提交时间：2022/08/16

Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold

 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 123, 页码: 12
作者:  Lu, Haibo;  Lu, Tian;  Zu, Shijia;  Duan, Zhe;  Guang, Yiman
  |  收藏  |  浏览/下载：24/0  |  提交时间：2022/08/16
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase 期刊论文  OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 798-808
作者:  Zheng, Yuandong;  Zhang, Hua;  Liu, Mengling;  Li, Guangze;  Ma, Sheng
  |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:  Chen, Cheng;  Ren, Yong-mei;  Zhu, Jian-zhong;  Chen, Jia-li;  Feng, Zhe-ling
  |  收藏  |  浏览/下载：52/0  |  提交时间：2022/01/04
Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy 期刊论文  OAI收割
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 19, 页码: 7381-7385
作者:  Lin, Bizhen;  Lu, Weiwei;  Chen, Zhen-yu;  Zhang, Yue;  Duan, Yin-zhe
  |  收藏  |  浏览/下载：26/0  |  提交时间：2021/12/01
Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219
作者:  Lu, Tian;  Li, Yong;  Lu, Wenchao;  Spitters, Twgm;  Fang, Xueyu
  |  收藏  |  浏览/下载：45/0  |  提交时间：2021/12/01
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088
作者:  Lu, Tian;  Lu, Haibo;  Duan, Zhe;  Wang, Jun;  Han, Jie
  |  收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs 期刊论文  OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 卷号: 117, 期号: 44, 页码: 27381-27387
作者:  Li, Zhe;  Li, Xin;  Huang, Yi-You;  Wu, Yaoxing;  Liu, Runduo
  |  收藏  |  浏览/下载：82/0  |  提交时间：2020/12/24
Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer 期刊论文  OAI收割
PHARMACEUTICS, 2019, 卷号: 11, 期号: 1, 页码: 16
作者:  Ci, Li-qian;  Huang, Zhi-gang;  Lv, Feng-mei;  Wang, Jun;  Feng, Ling-lin
  |  收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01