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浏览/检索结果: 共95条，第1-10条 帮助

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Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17
作者:  Li, Qian;  Zhang, Tao;  Song, Peiran;  Tong, Linjiang;  Feng, Fang
  |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17
Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034
作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang
  |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27
Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割
JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162
作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang
  |  收藏  |  浏览/下载：79/0  |  提交时间：2023/04/10
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations br 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang
  |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:  Chen, Hao;  Lai, Mengzhen;  Zhang, Tao;  Chen, Yuqing;  Tong, Linjiang
  |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/21
Characterizing and analyzing the sustainability and potential of China's cities over the past three decades 期刊论文  OAI收割
ECOLOGICAL INDICATORS, 2022, 卷号: 136, 期号: 0, 页码: 108635
作者:  Wang, Chenxing;  Quan, Yuan;  Li, Xiaoyun;  Yan, Yan;  Zhang, Jing
  |  收藏  |  浏览/下载：9/0  |  提交时间：2022/11/07
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR(T790M/C797S) Mutants 期刊论文  OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 7
作者:  Li, Shan;  Zhang, Tao;  Zhu, Su-Jie;  Lei, Chong;  Lai, Mengzhen
  |  收藏  |  浏览/下载：25/0  |  提交时间：2022/06/15
The chrysanthemum lavandulifolium genome and the molecular mechanism underlying diverse capitulum types 期刊论文  OAI收割
HORTICULTURE RESEARCH, 2022, 卷号: 9
作者:  
  |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/07
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文  OAI收割
CANCER SCIENCE, 2021, 页码: 12
作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang
  |  收藏  |  浏览/下载：87/0  |  提交时间：2022/01/18
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery 期刊论文  OAI收割
DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455
作者:  Xiang, Shuang;  Song, Shukai;  Tang, Haotian;  Smaill, Jeff B.;  Wang, Aiqun
  |  收藏  |  浏览/下载：35/0  |  提交时间：2021/12/01