中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [11]
大连化学物理研究所 [5]
宁波材料技术与工程研... [2]
计算技术研究所 [1]
心理研究所 [1]
上海应用物理研究所 [1]
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OAI收割 [24]
内容类型
期刊论文 [23]
会议论文 [1]
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2024 [2]
2023 [4]
2022 [3]
2021 [3]
2020 [3]
2019 [3]
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Instrument... [1]
Science & ... [1]
物理化学 [1]
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Targeting JMJD1C to selectively disrupt tumor T
reg
cell fitness enhances antitumor immunity
期刊论文
OAI收割
NATURE IMMUNOLOGY, 2024, 页码: 32
作者:
Long, Xuehui
;
Zhang, Sulin
;
Wang, Yuliang
;
Chen, Jingjing
;
Lu, Yanlai
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/25
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS
G12D
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Gu, Yuejiao
;
Ge, Zhiming
;
Tao, Zhaofan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
Sequence-based drug design as a concept in computational drug design
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 21
作者:
Chen, Lifan
;
Fan, Zisheng
;
Chang, Jie
;
Yang, Ruirui
;
Hou, Hui
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/10/17
Multi-source underwater DOA estimation using PSO-BP neural network based on high-order cumulant optimization
期刊论文
OAI收割
CHINA COMMUNICATIONS, 2023, 页码: 18
作者:
Chen, Haihua
;
Zhang, Jingyao
;
Jiang, Bin
;
Cui, Xuerong
;
Zhou, Rongrong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/04
Direction-of-arrival estimation
Estimation
Neural networks
Mathematical models
Training
Covariance matrices
Biological neural networks
particle swarm optimization (PSO) algorithm
PSO-BP neural network
gaussian colored noise
multiple sources
higher-order cumulant
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214
作者:
Zhou, Zehui
;
Zhou, Guizhen
;
Zhou, Chuan
;
Fan, Zisheng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/27
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3327-3347
作者:
Shan, Bin
;
Hou, Hui
;
Zhang, Keke
;
Li, Rui
;
Shen, Chang
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/27
Obsessive-compulsive disorder in Chinese methamphetamine patients: Prevalence, demographics, and clinical characteristics
期刊论文
OAI收割
AMERICAN JOURNAL ON ADDICTIONS, 2022, 页码: 5
作者:
Liu, Siying
;
Wan, Jiaxue
;
Liang, Qilin
;
Tian, Yang
;
Fan, Fusheng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/01/16
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 5, 页码: 3923-3942
作者:
Zhou, Chuan
;
Fan, Zisheng
;
Zhou, Zehui
;
Li, Yupeng
;
Cui, Rongrong
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/06/15
Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1, 页码: 103-119
作者:
Tan, Xiaoqin
;
Li, Chunpu
;
Yang, Ruirui
;
Zhao, Sen
;
Li, Fei
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/06/15
Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22, 页码: 16838-16853
作者:
Ding, Xiaoyu
;
Cui, Rongrong
;
Yu, Jie
;
Liu, Tiantian
;
Zhu, Tingfei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/06/15