中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
西北高原生物研究所 [19]
上海药物研究所 [15]
地理科学与资源研究所 [5]
地质与地球物理研究所 [4]
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上海硅酸盐研究所 [4]
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期刊论文 [73]
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2023 [3]
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Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287
作者:
Hu, Linghao
;
Li, Huiyun
;
Qin, Junlin
;
Yang, Dan
;
Liu, Jieming
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/02/27
Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naive major depressive disorder
期刊论文
OAI收割
FRONTIERS IN PSYCHIATRY, 2023, 卷号: 14, 页码: 9
作者:
Liu, Junjun
;
Zhu, Xiaomin
;
Liu, Yang
;
Jia, Fengnan
;
Yuan, Hsinsung
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/09
triglyceride glucose index
suicide attempts
insulin resistance
major depressive disorder
association
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma
期刊论文
OAI收割
CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 15
作者:
Jiang, Xifei
;
Deng, Wenjia
;
Tao, Siyao
;
Tang, Zheng
;
Chen, Yuehong
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/04/10
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15
作者:
Yu, Xiaolu
;
Long, Yiru
;
Chen, Binfan
;
Tong, Yongliang
;
Shan, Mengwen
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/12/13
PD-L1
TLR7
nanobody-drug-conjugate
cancer immunotherapy
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8
作者:
Li, Linjie
;
Su, Mingbo
;
Lu, Weiwei
;
Song, Hongzhi
;
Liu, Jiaxiang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
DNA encoded library
covalent library
library design
covalent inhibitors
Discovery of a Potent and Selective Degrader for USP7
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395
作者:
Pei, Yuan
;
Fu, Jingfeng
;
Shi, Yunkai
;
Zhang, Mengmeng
;
Luo, Guanghao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/21
Apoptotic Pathway
Mutant p53
p53 Mutant Cancer Cells
PROTAC
USP7 Degrader
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15
作者:
Zhu, Cheng-Liang
;
Luo, Xiaomin
;
Tian, Tian
;
Rao, Zijian
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/08/16
AKT
Protein kinase B
PROTAC
Chemical degrader
Rational design
Selection of internal reference gene for normalization of reverse transcription-quantitative polymerase chain reaction analysis in Mycoplasma hyopneumoniae
期刊论文
OAI收割
FRONTIERS IN VETERINARY SCIENCE, 2022, 卷号: 9, 页码: 11
作者:
Li, Shiyang
;
Zhou, Yanqing
;
Yuan, Ting
;
Feng, Zhixin
;
Zhang, Zhenzhen
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/08/30
Mycoplasma hyopneumoniae
RT-qPCR
real-time quantitative polymerase chain reaction
internal reference genes
gatB
virulence
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 9096–9125
作者:
Zhang, Jingyu
;
Che, Jinxin
;
Luo, Xiaomin
;
Wu, Mingfei
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/21