中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [28]
化学研究所 [22]
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期刊论文 [137]
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浏览/检索结果:
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Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK)
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19
作者:
Cheng, Jing
;
Yan, Ziqin
;
Li, Xinzhi
;
Liu, Chen
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/08
Kinase inhibitor
NIK
NF-KB2
Indoline
COT
Cytotoxicity
Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092
作者:
Qin, Shaozhao
;
Feng, Lijian
;
Zhao, Qingyi
;
Yan, Ziqin
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/02/27
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/02/19
Method of Selecting Active Parameters Using Sensitivity Analysis and Linear Programming
期刊论文
OAI收割
COMBUSTION SCIENCE AND TECHNOLOGY, 2023, 页码: 17
作者:
Li, Yujun
;
Zhang, Taichang
;
Fang, Yunming
;
Fan, Xuejun
;
Fan XJ(范学军)
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/28
Active parameter
sensitivity analysis
linear programming
selection method
chemical kinetic model
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 871, 页码: 13
作者:
Zhao, Xiaoran
;
Wang, Qing
;
Li, Xiangfei
;
Xu, Hua
;
Ren, Chuanbo
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/11/15
Progestin
Histology
Transcriptome
Metabolome
Bivalve
Optical tuning and energy transfer of single-phase white-emitting Y3TaO7:Bi3+, Eu3+ for ultraviolet converted pc-WLED with high chromatic stability
期刊论文
OAI收割
JOURNAL OF ALLOYS AND COMPOUNDS, 2023, 卷号: 940, 页码: 10
作者:
Xue, Yali
;
Liang, Yujun
;
Dou, Yi
;
Li, Haoran
;
Wang, Qiangke
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2023/05/19
Energy transfer
Chromatic stability
WLEDs application
Y3TaO7:Bi3+, Eu3+
Intelligent method for parameters optimization of cable in soft rock tunnel base on longitudinal wave velocity
期刊论文
OAI收割
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY, 2023, 卷号: 133, 期号: -, 页码: -
作者:
Li, Gan
;
Zhu, Chun
;
He, Manchao
;
Zuo, Yujun
;
Gong, Fengqiang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/08/02
Support optimization design
P-wave velocity
Joint density
Anchor support
Neural network
An experimental investigation of supersonic combustion of cracked JP-10
期刊论文
OAI收割
ACTA ASTRONAUTICA, 2023, 卷号: 203, 页码: 329-340
作者:
Cui, Naifu
;
Rao, Wei
;
Li, Yujun
;
Zhu, Yinhai
;
Zhang, Taichang
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/02/07
Cracking
JP-10
Supersonic combustion
Regenerative cooling
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 1, 页码: 157-173
作者:
Sun, Mingming
;
Li, Leilei
;
Niu, Yujia
;
Wang, Yingzhi
;
Yan, Qi
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/27
Lung cancer
Metabolic reprogramming
Post-translational modification
PRMT6
Pentose phosphate pathway flux
Glycolysis
6-Phospho-gluconate dehydrogenase
a-enolase
ENO1